Precision Medicine Biomarker Senior Scientist

Join us as we transform immunology and deliver medicines that help autoimmune patients get their lives back. argenx is preparing for multi-dimensional expansion to reach more patients through a rich pipeline of differentiated assets, led by VYVGART, our first-in-class neonatal Fc receptor blocker approved for the treatment of gMG, and with the potential to treat patients across dozens of severe autoimmune diseases.

We are building a new kind of biotech company, one that maintains its roots as a science-based start-up and pushes our commitment to innovate across all corners of our business. We strive to inspire and grow our company, our partnerships, our science, and our people, because when we do, we deliver more for patients. 

argenx is a fast-growing, clinical-stage biopharmaceutical company focused on developing innovative antibody-based therapies to improve the lives of people with severe autoimmune diseases. Leveraging our unique antibody engineering technologies and the complementary expertise of our global team, we have built a differentiated pipeline of novel product candidates, tailored from discovery through development to meet specific patient needs. As we expand our therapeutic franchises across neuromuscular, neurology, rheumatology, and nephrology indications, we remain deeply committed to our core values of collaboration, empowerment, humility, innovation, and excellence—always staying science-based, data-driven, and patient-focused.

We are seeking a highly motivated Senior Scientist with expertise in immunology research and biomarker data analysis to join our Translational Science team. The successful candidate will play a key role in supporting and leading biomarker strategies, enabling stratified medicine/diagnostic approaches, and advancing the probability of successful drug development and approval.

This position is based at our facility in Zwijnaarde, Belgium, and requires regular on-site presence in combination with remote working possibilities.
We look forward to receiving your CV and cover letter when applying. A cover letter is mandatory for your application to be considered.

Main responsibilities

Biomarker Strategy & Implementation

• Drive precision medicine strategies while leveraging assay technology expertise, technical knowledge, disease understanding, and patient needs.
• Participate in the selection, development, and validation of predictive, pharmacodynamic, and safety biomarkers, including biomarkers supporting treatment response, disease understanding and Mode-of Action.
• Translate biomarker context of use (COU) into analytical requirements and ensure fit-for-purpose assay and vendor selection.
• Drive the implementation of biomarker assays and sample analysis, collaborating with internal and external teams, including omics approaches
• Act as an interactor between biomarker and translational scientists, ensuring alignment of biomarker strategies with translational research objectives.
• Collaborate closely with Medical Affairs and Commercial teams to ensure biomarker insights support clinical positioning and market access strategies.
• Contribute to reverse translation efforts, using clinical data to inform preclinical research and future biomarker development.
   

Biomarker Data Analysis & Interpretation

• Support Biomarker Data Science team to ensure data is analysed in line with COU, assay capabilities and clinical development strategy.
• Contribute to the FAIRification of biomarker data and their metadata.
• Collaborate with cross-functional teams to integrate biomarker findings into drug discovery and development decisions, including patient selection and dose optimization.
• Act as a liaison between scientific teams and data scientists during statistical analysis plan (SAP) development, ensuring research questions and objectives are accurately reflected.
• Gather and clarify requirements from scientists and stakeholders for data scientists and statisticians.
• Interpret analysis results provided by statisticians or data scientists and partner to summarization of key findings.
• Prepare clear, scientifically robust reports and presentations of insights and implications of results to scientific internal stakeholders, regulatory submissions, and external publications.
   

Innovation & Framework

• Support the build and maintenance of data storage solutions for translational activities and ensure compliance with FAIR data principles.
• Stay current with emerging technologies, analytical methods, and regulatory guidance in biomarker research.
• Contribute to the implementation of novel data analysis and biomarker identification approaches, including machine learning and