Senior Scientist, DMPK - 2445

At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.  

We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization. 

Together, we are leading the way towards a healthier and more equitable future. 

Position Summary 

Editas Medicine is seeking a highly motivated, energetic and collaborative scientist to join our DMPK, Nonclinical Safety and translational sciences team (DSTS). The successful individual will apply drug metabolism and pharmacokinetic (DMPK) knowledge and expertise to support both preclinical and clinical programs at Editas. This individual will be responsible for contributing to our scientific strategy, designing preclinical studies, establish new capabilities in-house as well as work with contract research organizations (CROs) when appropriate to support our gene editing programs. The ideal candidate will have a diverse experimental skill set, a broad understanding of drug discovery and development, strong foundational DMPK knowledge and ability to work collaboratively with key partners in a matrix team structure. In addition, the candidate should possess qualities such as creative and independent thinking, a positive and team-centered attitude, and an ability to thrive in a fast-paced environment. Prior experience with lipid nanoparticle based (LNP) delivery systems and nucleic acid therapeutics is a plus. This highly visible position allows for interaction with both discovery and clinical development teams to bring life changing therapies to patients with genetic disorders.

Key Responsibilities

As the Senior Scientist, you will be responsible for:

• Guide, conduct/oversee in vitro and in vivo preclinical studies.
• Analyze data generated from the preclinical studies using standard techniques including PK analysis using various modeling approaches, as appropriate.
• Evaluate exposure-response relationship for assessing target engagement considering efficacy, PK, biomarkers and safety.
• Predict preclinical and clinical PK; Contribute to FIH dose prediction.
• Develop, validate, and implement ADME assays, as needed.
• Interact with and oversee activities at CROs including working with operations team for the successful transfer of assays .
• Work collaboratively with other scientists within and outside the function including platform research, chemistry, operations, clinical.
• Ability to effectively communicate and clearly articulate logistical and technical challenges across the organization.
• Maintain excellent practices across all documentation including electronic lab notebooks.
• Write, review, and contribute to pre-clinical study protocols and reports to support regulatory filing documents.

Requirements

Required Qualifications 

• The ideal candidate will possess: 
• PhD in pharmaceutics, pharmacology, or related fields with 5+ years of industry experience is required. Outstanding candidates with a Master’s degrees and at least 8+ years of relevant proven industry experience may also be considered.
• Strong foundation in DMPK and experience with PK and/or PK/PD analysis using modeling software such as WinNonLin is required.

Preferred Qualifications 

• Additionally, candidates with the following attributes are preferred: 
• Proven ability to design experiments, troubleshoot, interpret, and report data.
• Excellent interpersonal, organizational, oral/written communication and presentation skills.
• Proven ability to work successfully in a team environment.
• Strong scientific writing skills and verbal communication.
• Exhibits high degree of integrity and professionalism.

Benefits

Benefits Summary:

Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

If you are a results-focused and collaborative professional with a passio