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Research Associate/Senior Research Associate, High Throughput Screening
Korro BioUnited Statesfull_timeVerifiedPosted 26 Sept 2024
About the role
Company Summary: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro’s lead program is Alpha-1 Antitrypsin Deficiency (AATD). Korro is based in Cambridge, Massachusetts.
We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.
Position Summary: We are seeking a highly motivated, Research Associate/Senior Research Associate to join our High Throughput Screening group. They will be responsible for the design, execution, and analysis of a variety of high throughput screens and will participate in the development and scaling of novel assays as we continue to build our RNA editing platform. The candidate must have demonstrated proficiency in the deployment of cell-based models and assays for drug candidate screening. In addition, the candidate will help design, validate, and implement high throughput NGS and qPCR/dPCR based assays. The candidate should have a proven ability to design and implement thoughtful and well controlled experiments. The right candidate should also be comfortable working with various types of automated high throughput equipment. The candidate will be a motivated team player, have excellent interpersonal and communication skills and be able to balance multiple high-priority tasks in a rapidly changing environment.
We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.
Position Summary: We are seeking a highly motivated, Research Associate/Senior Research Associate to join our High Throughput Screening group. They will be responsible for the design, execution, and analysis of a variety of high throughput screens and will participate in the development and scaling of novel assays as we continue to build our RNA editing platform. The candidate must have demonstrated proficiency in the deployment of cell-based models and assays for drug candidate screening. In addition, the candidate will help design, validate, and implement high throughput NGS and qPCR/dPCR based assays. The candidate should have a proven ability to design and implement thoughtful and well controlled experiments. The right candidate should also be comfortable working with various types of automated high throughput equipment. The candidate will be a motivated team player, have excellent interpersonal and communication skills and be able to balance multiple high-priority tasks in a rapidly changing environment.
Key Responsibilities:
- Help design, validate, and implement high throughput NGS and qPCR/dPCR based assays using various types of automated high throughput equipment.
- Deploy cell-based models and assays to screen drug candidates.
- Participate in the development and scaling of various in vitro assays.
- Collect and interpret data and present at research updates to various project teams.
Required Qualifications:
- BS/MS with 2 – 5 years of experience in molecular and/or cell biology, or related field.
- Experience with mammalian cell culture, aseptic technique and cell0based assays in 96 and, preferably 384-well format.
- Broad experience in the application of biochemical and cell-based techniques, such as mammalian cell culture, transfections, qPCR, NGS, dPCR.
- Familiarity in the use of lab automation, liquid handling, and HTS instrumentation is preferred.
- The ability to learn and implement new techniques and adapt rapidly are essential. Excellent attention to detail, time management, and documentation.
- The candidate must be able to analyze, report and communicate data rigorously.
- Ability to multitask and successfully interact with a diverse team of scientists to deliver quality data and results.
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