Scientist or Senior Scientist, In Vivo Pharmacology

The Company 

At Sonata Therapeutics, a Boston-based Flagship Pioneering company, we are revolutionizing the world’s understanding of the cellular microenvironment and their importance to human biology and disease. Our product-platform creates drugs based on a systematic, comprehensive characterization of the microenvironment in diseases with high unmet medical need. Through our pioneering science, we identify new targets for therapeutics that induce the release of a programmed diversity of signals with the potential for significant patient impact.  
  
Sonata Therapeutics was founded by Flagship Pioneering, an organization dedicated to the origination and development of first-in-category life sciences companies.  Since 2000, Flagship has originated and fostered the development of nearly 100 scientific ventures resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.    
  

The Position

Due to the expansion of our R&D capabilities, we are currently looking for an enthusiastic, innovative, and highly motivated scientist to join our In Vivo Pharmacology team. The candidate will play a vital role in building out our internal in vivo pharmacology capabilities and help us advance the cutting-edge science to drive anti-tumor immune activation through diverse therapeutic modalities. The position will require creativity, resourcefulness, and adaptability. The candidate must be independent and goal oriented, and able to efficiently lead assigned in vivo projects and complete multiple projects in parallel.

We offer the exciting and potential opportunity to work at an early-stage, big concept biotechnology company. Your efforts will have a lasting impact on our development programs leading to future success in the clinic.

 

Crucial responsibilities

• Design, analyze, and interpret decision-making in vivo pharmacology experiments in support of diverse projects across our portfolio (e.g., Oncology, Immuno-oncology); play a role as an in vivo pharmacology representative in projects working on.
• Execute and actively support in vivo research efforts in-house.
• Interact closely with cross-functional discovery teams and contribute to decision-making through scientific expertise

 

Education and industry experience

Bachelors, Masters, PhD or equivalent in Cancer biology, Immunology, or other biological sciences with 2+ years of additional industry experience

 

As a strong candidate, you

• Must have hands-on experience in evaluating therapeutic candidates in vivo models.
• Must have a strong background in oncology and have extensive experience carrying out in vivo studies including efficacy and PK/PD.
• Must possess the ability to adapt and leverage your superior problem-solving skills in a fast-paced environment and the flexibility to change priorities as needed.
• Have experience in working with cross-functional discovery teams; must demonstrate superior presentation/verbal communication skills to successfully influence cross-functional teams by promoting clear decision-making based on scientific expertise.

Preferred technical skills and work experience

• Include administering treatments to rodents (e.g., PO, IV, IP, SC, Intratumoral dosing); preparation and formulation of compounds for dosing; blood collection (e.g., cardiac puncture, tail vein serial microsampling, submandibular blood collection); rodent tissue collection and necropsy.
• Include work experience with oncology model-related activities (e.g., tumor cell culture, cell inoculation, tumor measurement) in syngeneic, CDX, PDX models.
• Include work experience with IVIS imaging.

 

 
Sonata Therapeutics and Flagship Pioneering are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.   #LI-JRF