Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

The Senior Associate Scientist will be responsible for working with fellow scientists to make pDNA, carry out Invitro transcription reaction (IVT) and purify a variety of macromolecules including; DNA template, RNA drug substance, LNP drug product, antibody purification, and recombinant proteins. Responsibilities will include UF/DF, affinity chromatography, column packing, testing and analysis of in-process samples.

The Senior Associate Scientist will be expected to summarize, evaluate the study results, and document the recovery of purification processes. It is also expected that the incumbent will perform analysis/ characterization of isolated macromolecules with various bioanalytical methodologies. Careful documentation of work and presentation of data is required.   The job function requires judgment and innovation to achieve a solution within standard practices and procedures.  Responsibilities will include conducting experiments, tests, and analysis as part of a variety of research and development activities.   

How You Will Achieve It

• Compliance with all Standard Operating Procedures (SOPs). 

• Responsible for generating in-process data and batch records.  Works directly with analysts to actively trouble-shoot activities. 

• Complete all required training courses in compliance with departmental requirements and follow appropriate safety practices in the workplace. 

• Develop and optimize processes where needed 

• Collaborate with colleagues within Vaccine Research and Development organization including Bioprocess Fermentation, Analytical, and Formulation Development groups. 

• Perform upstream and downstream processing of materials in a timely and compliant manner 

• Perform assays on vaccine products, process intermediates, and related experimental samples using biochemical/analytical tests. 

• Prepare solutions/reagents. 

• Present problems and propose solutions in discussions with group members.  

• Perform assays on vaccine products, process intermediates, and related experimental samples using biochemical/analytical tests. 

• Satisfactorily complete all safety training in compliance with departmental requirements and follow appropriate safety practices in the workplace 

• Perform timely notebook entries and review for completed experiments. 

• Plan and prioritize related recovery / purification activities. 

• Perform timely notebook entries and review for completed experiments. 

Qualifications

Must-Have

• BS degree with 3-5 years relevant experience, or a MS degree with 0-2 years relevant experience  

• A strong background in protein biochemistry, biophysics, and separation techniques is essential. Hands on experience with DNA isolation, PCR, IVT and purification is preferred.  

• Prior experience with bio-processing/purification.  

• Experience running chromatography experiments with AKTA systems using UNICORN software.