Executive Director, Clinical Pharmacology

Janux Therapeutics is seeking a hands-on, execution-driven Executive Director of Clinical Pharmacology to lead the design, analysis, and interpretation of clinical pharmacology strategies across our development programs. This role is ideal for a scientific leader who thrives on rolling up their sleeves, working closely with data, and directly influencing clinical and regulatory outcomes.
As a key member of the clinical development leadership team, you will be responsible for both strategic direction and day-to-day execution of clinical pharmacology deliverables. You’ll work cross-functionally to ensure that pharmacokinetic (PK), pharmacodynamic (PD), and exposure-response data are fully leveraged to guide dose selection, study design, and regulatory strategy.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

• Serve as the Clinical Pharmacology Lead for multiple programs, owning the strategy and execution of clinical pharmacology plans from IND through late-stage development.
• Design and oversee PK, PK/PD, and exposure-response analyses to support dose selection, study design, and benefit-risk assessments.
• Lead the development and execution of clinical pharmacology studies, including food effect, drug-drug interaction, organ impairment, and QT assessments.
• Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs, briefing books) and represent Janux in regulatory meetings.
• Ensure proper bioanalytical sampling strategies, assay validation, and data quality across studies.
• Partner with Translational, Pharmacology and/or Biomarker teams to integrate biomarker and mechanistic data into PK/PD models and clinical decision-making.
• Work closely with Biometrics to develop and validate population PK and exposure-response models.
• Provide scientific leadership and mentorship to internal team members, fostering a culture of collaboration, innovation, and accountability.
• Contribute to portfolio-level planning, helping prioritize programs and allocate resources based on pharmacological insights and development risk.
• Stay current with regulatory guidance and scientific advances in clinical pharmacology, applying best practices to Janux’s development programs
• Other activities as required.

REQUIRED EDUCATION, EXPERIENCE, SKILLS, AND ABILITIES

• Ph.D., Pharm.D., or equivalent in Clinical Pharmacology, Pharmaceutical Sciences, or a related field.
• 10+ years of experience in clinical pharmacology and/or pharmacometrics in the biotech or pharmaceutical industry.
• Direct experience designing and executing early-phase clinical studies, including those involving healthy volunteers. Experience in oncology will be highly preferred.
• Demonstrated success in leading clinical pharmacology strategy and execution across multiple programs, in all phases of development.
• Deep expertise in model-informed drug development (MIDD), including population PK, PK/PD modeling, and exposure-response analysis.
• Strong track record of contributing to regulatory submissions and engaging with global health authorities.
• Excellent communication, leadership, and cross-functional collaboration skills.
• Strong organizational and time management abilities.
• High level of accountability, adaptability, and attention to detail.
• Ability to work independently and collaboratively in a fast-paced, matrixed environment.
• Ability to travel up to 15%

Job Type: Full-time Benefits:·         401K·         Medical insurance·         Dental insurance·         Vision insurance·         Supplemental disability insurance plans·         Flexible schedule·         Life insurance·         Flexible vacation·         Sick time·         Incentive stock option plan·         Relocation assistance Schedule:·         Monday to Friday Work authorization:·         United States (Required) Additional Compensation:·         Annual targeted bonus X% Work Location:·         On site (San Diego, CA) EQUAL OPPORTUNITY EMPLOYER:Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environ