Senior Research Associate II, Inflammation Biology

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Job Description
 

We are seeking a highly motivated Senior Research Associate to join our inflammation group.  The candidate will be responsible for evaluating novel therapeutics in pre-clinical models of autoimmune and inflammatory diseases. Hands-on experience and  knowledge of preclinical models of inflammatory autoimmune diseases is required. The successful candidate will be responsible for execution of in vivo mouse studies, ex vivo phenotyping of tissues and generating and communicating pharmacology data of preclinical models internally to support inflammatory target discovery for autoimmunity.

Primary responsibilities:

·       Designing, conducting, analyzing and reporting in vivo studies (efficacy, PK/PD).

·       Pre-clinical model development, optimization, and characterization.

·       Ex vivo phenotyping of the immune response, using techniques such as animal tissue processing to isolate immune cells, multicolor flow cytometry to assess immune cell phenotype and function, gene expression profiling and ELISA.

·       Coordinating shipment of ex vivo samples as needed.

·       Interface with cross-functional project team members, and participation in and presentation at project team meetings and cross-departmental team meetings.       

Qualifications & prior experience:

·       Bachelors or M.S. in Biology or Pharmacology related discipline.

·      2-4 years of research experience in an industry setting or academic research institution with understanding of inflammatory disease pathogenesis.

·        Hand-on research experience with mouse models of inflammation and proficiency with various mouse handling techniques including dosing (IV, PO, subcutaneous, IP), preclinical manifestation scoring (e.g., joint swelling, paralysis), and collection and handling of tissues during necropsy and processing for ex vivo analysis.

·       Experience with processing tissues for flow cytometry and flow cytometric analysis is required.

·       Excellent organizational and communication skills, along with the ability to work effectively in a multidisciplinary team environment.

·       The ability to work independently on day-to-day responsibilities and research goals along with strong attention to detail.