Supervisor – Isotope Production

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/

The Supervisor – Isotope Production, reporting to the Associate Director – Radiopharmaceuticals, plays a critical role in delivering RayzeBio’s innovative radiopharmaceutical products to patients. This position supports the implementation and routine execution of a novel isotope production program manufacturing clinical and commercial‑scale radioisotopes.

The Supervisor – Isotope Production provides day‑to‑day operational leadership for isotope production activities and serves as a key point of contact on the production floor, coordinating and guiding a team of operators working under Good Manufacturing Practices (GMP). This role is also a frontline leader for radiation safety, compliance, and operational discipline within the manufacturing suites.

Job Responsibilities

Essential duties and responsibilities include the following. Other duties may be assigned.

• Provide day‑to‑day operational oversight of radioisotope production activities, including scheduling, material preparation, line clearance, equipment setup, and batch record execution, ensuring compliance with GMP, NRC regulations, and internal expectations.

• Serve as a functional lead for production operators by providing guidance, task coordination, and on‑the‑floor support to ensure safe, compliant, and efficient execution of manufacturing activities.

• Support onboarding and training efforts for production staff and promote adherence to GMP and radiation safety best practices during manufacturing activities.

• Support and execute validation activities associated with isotope production at the clinal and commercial scale.

• Collaborate with cross‑functional partners including Quality, Safety, Engineering, Development, and Management to identify opportunities for process optimization, troubleshooting, and continuous improvement.

• Assist Isotope Production Management with the compilation of operational KPIs and support the investigation and resolution of quality events (e.g., deviations, OOS, and nonconformances).

• Support inventory management activities, including consumables, spare parts, cleaning supplies, and personal protective equipment (PPE)

• Promote and reinforce a strong culture of safety, quality, and compliance with EHS and Radiation Safety programs.

• Author, review, and revise production technical documentation (e.g., SOPs, forms, batch records) as needed to support manufacturing operations.

Education and Experience:

• Demonstrated experience leading work activities, mentoring peers, or serving in a lead or senior operational role within a manufacturing or laboratory environment; prior formal supervisory experience is beneficial but not required.

• 3–5 years of experience operating in a GMP‑regulated environment.

• Hands‑on experience working in hot cells and/or gloveboxes strongly preferred.

• Associate’s or Bachelor’s degree in a STEM field preferred, or equivalent combination of education and relevant experience.

Skills and Qualification:

• Fluency in English.

• Strong knowledge of GMP practice.

• Knowledge of radiation safety principles.

• Excellent professional ethics, integrity, and ability to maintain confidential information.

• Utilizes AI tools to enhance individual productivity and quality of work

• Well organized and detail oriented.

• Strong interpersonal communication skills.

• Motivated, adaptable, and able to work under pressure while meeting the needs of the production schedule.

Physical Demands:

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally