Postdoctoral Fellow-MSH-30025-233

Title: post doc

Salary: starting post doc salary (minimum)

Department: Onc Sci

Physical work location: (must be proper street address)

Hess Center for Science and Medicine
1470 Madison Avenue,  6th Fl., Rm. 105
New York, New York 10029

Name PI or Supervisor: (include phone and email)

Ernesto Guccione

Phone: (212 824-8863). Ext. 58863 
Ernesto.guccione@mssm.edu

 

Web link to Lab: https://www.guccionelab.com/

Web link to Department: https://icahn.mssm.edu/research/center-oncogenomics

 

Administrative Contact: (phone and email)

shaniece.dunlap@mssm.edu

(212) 241-3008

Details of Research Project: 

Targeting cancer stem cells (CSCs) is crucial for effective cancer treatment. However, the molecular mechanisms underlying resistance to LGR5+ CSCs depletion in colorectal cancer (CRC) remain largely elusive. As part of this post-doctoral project the candidate will explore the role of oncofetal (OnF) reprogramming of the LGR5+ stem cells (SCs) in the context of WNT-driven CRC lineage plasticity. Drug and genetic screening will be initiated to uncover targetable vulnerabilities in CRC.

Technical Duties: (include any protocols)

Organoid and mouse work.

Multiomics NGS techniques

Molecular/mechanistic experimental design and execution.

Educational and other Requirements for the position: PhD

Experience Required: Organoid culture and knowledge of intestinal tumorigenesis

Goals/Outcomes of the Research Project: 

Identification of novel therapeutic intervention in CRC

 

Compensation Statement

The Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for this role is $73,588.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 824 - Oncological Sciences - ISM, Icahn School of Medicine

 

EOE Minorities/Women/Disabled/Veterans

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:  

• Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.
• Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.
• Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization.  We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally.

 Explore more about this opportunity and how you can help us write a new chapter in our history!

“About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro