Senior Scientist, Modeling - Global DMPK&M

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Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Quantitative Systems Pharmacology Modeler - Senior Scientist in our Cambridge, MA location.

Objective / Purpose:

As a Quantitative Systems Pharmacology Modeler - Senior Scientist in DMPK & Modeling, you will be empowered to interface between clinical pharmacology, clinical research, nonclinical drug safety, drug discovery, drug metabolism, translational medicine and pharmacovigilance to influence drug development.

Accountabilities:

• Support decision making in the preclinical development of novel therapeutic agents to treat various diseases involving aberrant activation of the immune system, including irritable bowel disease (IBD), ulcerative colitis, liver fibrosis, dermatitis, and others.
• Work on cross-functional teams with preclinical biology/pharmacology, clinical pharmacology, nonclinical safety assessment, and translational medicine to develop quantitative model-based understanding of both the target biological pathways and novel therapeutic agents.
• May involve early feasibility assessment for novel targets, reverse translation from clinical comparators for validates ones, and/or building pharmacokinetic/pharmacodynamic (PK/PD), physiologically based pharmacokinetic (PBPK), and quantitative systems pharmacology (QSP) models for distribution, pharmacology, and efficacy of novel agents.
• Implement a modeling & simulation strategy to assist and accelerate decisions around preclinical study design and interpretation, as well as prediction of first-in-human dose and safety margins for clinical trials. 

Education & Competencies

• Ph.D/Pharm.D in chemical or biomedical engineering, pharmaceutical sciences, mathematics, physics, or equivalent area.
• Strong competency in building mathematical models is required (in commonly used languages such as MATLAB, SimBiology, NONMEM, Phoenix, Python, or R)  
• At least 2 years (8 years with MS) of industry experience in mathematical modeling of biological systems.
• Demonstrated strong analytical skills to evaluate complex information and identify key scientific questions related to projects.
• Ability to communicate complex modeling results clearly and concisely to cross-functional audience is critical.

• Prefer candidates with background or interest in immunology or biology of GI diseases. 

• Job title is flexible based on experience. 

This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy

Takeda Compensation and Benefits Summary

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