Location

ST. LOUIS, MO 63110

Scheduled Hours

40

Position Summary

Our laboratory is dedicated to advancing the understanding of vascular biology, with a particular emphasis on the mechanisms that drive vascular dysfunction and remodeling in disease. A central focus of our work is hypoxia-induced pulmonary hypertension, a devastating condition characterized by maladaptive changes in the pulmonary vasculature that culminate in elevated pressures and right heart failure. We investigate how low oxygen tension alters cellular signaling and vascular homeostasis, leading to activation, injury, and reprogramming of key vascular cell types, including endothelial cells, smooth muscle cells, pericytes and fibroblasts.

By mapping the molecular interactions and signaling networks that govern these processes, we aim to uncover the drivers of pathological remodeling. In parallel, we are interested in the regenerative capacity of vascular tissues and the potential for cellular reprogramming to restore function. This includes dissecting pathways of vascular regeneration, repair, and plasticity that could be harnessed to reverse damage.

Our integrated approach spans molecular, cellular, and in vivo systems to bridge fundamental biology with translational discovery. Ultimately, the goal of our research is not only to illuminate the underpinnings of vascular pathology, but also to exploit these insights for development of novel therapeutic strategies. By targeting maladaptive signaling and promoting regenerative programs, we strive to pioneer innovative treatments for pulmonary hypertension and other vascular diseases.

Performs independently complex research studies, experiments and assays.

Job Description

• Performs complex analysis/projects according to research protocols, explaining methods and procedures to other technicians.
• Enters data and maintains current data files on research projects. Monitors data to ensure consistent quality.
• May perform preliminary statistical analysis of data.
• Assures compliance with established safety procedures and maintains required documentation on laboratory and specimen conditions.
• Ensures lab conditions and equipment are properly cleaned and maintained in accordance with established procedures.
• Assists in the training and development of technicians, acting as a group leader.
• Performs other duties as assigned.

Working Conditions:

• Works in a laboratory environment with potential exposure to biological and chemical hazards.
• Must be physically able to wear protective equipment and to provide standard care to research animals.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Master’s degree or combination of education and/or experience may substitute for minimum education.

Certifications/Professional Licenses:

No specific certification/professional license is required for this position.

Work Experience:

Laboratory Setting (1 Year)

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

More About This Job

Preferred Qualifications:

• Experience working with small animals.

Preferred Qualifications

Education:

No additional education unless stated elsewhere in the job posting.

Certifications/Professional Licenses:

No additional certification/professional licenses unless stated elsewhere in the job posting.

Work Experience:

No additional work experience unless stated elsewhere in the job posting.

Skills:

Communication, Laboratory Instrumentation, Recordkeeping, Software Program, Working Independently

Grade

R08-H

Salary Range

$18.77 - $31.94 / Hourly

The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in