Staff Research Associate III - Neurology

General Information

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Work Location: Los Angeles, USA Onsite or Remote Fully On-Site Work Schedule Monday-Friday, 8:00am-5:00pm Posted Date 04/07/2025 Salary Range: $66431 - 106830 Annually Employment Type 4 - Staff: Limited Duration 9 months Job # 23687

Primary Duties and Responsibilities

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The Staff Research Associate III (SRA III)  will be responsible for oversight of the lab and research. Using laboratory skills in molecular genetics/genomics, the SRAIII will undertake several research studies under supervision of the lab director/PI.

The following tasks include but are not limited to:

• Conduct genetic family studies in multiplex, multigeneration families with juvenile myoclonic epilepsy and linkage based whole exome sequencing of identical by descent (identical by epilepsy and EEG spike waves) family members in order to identify candidate epilepsy causing variants (mutations) of a putative epilepsy gene
• Screen for more variants of the putative epilepsy gene in 300 to 500 singletons and families with JME 
• Vet the candidate variants of the putative epilepsy gene through the US National Human Genome Institute  (NHGRI) and American College of Medical Genetics and Genomics (ACMG) guidelines to assign genetic implication and pathogenicity
• Generate a transgenic KO mice model of the putative epilepsy gene to determine if the epilepsy phenotypes of human JME are replicated 
• Perform functional studies of the candidate epilepsy gene to assess if the candidate variants damage the normal functions of the putative epilepsy gene.

Please note: This is a part-time 9-month limited position and may convert to career.
Salary Range: $66431.27 - $106830.32/Annually

Job Qualifications

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Required:

• Ability in designing research strategies, designing experiments, and establishing new laboratory procedures and protocols.
• Experience in managing general responsibilities such as ordering, maintenance of blood/DNA stored in -80 degrees freezer, and maintenance of general lab equipment.
• Ability to lead and teach students and postdoctoral fellows, processing data, interpreting results of western blotting, whole genome or whole exome sequencing.
• Training and experience in library making and data analysis of next generation sequencing as well as in different genotyping techniques, Sanger sequencing and other molecular, biochemical and cellular culture results.
• Abil