Principal Scientist / Associate Director Translational Informatics

At AstraZeneca, we win through the science, it is at the heart of our every success. Every decision is rooted in the limitless possibilities of what science can do. We push the boundaries of science to deliver medicines. This purpose underpins everything we do. It gives us a reason to come to work every day. It reminds us why we exist as a company. It helps us deliver benefits to patients and build new value for shareholders. It also sets the context for our employees’ activities and the roles of our teams, partners, and other collaborators. AstraZeneca has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Introduction to role:

Are you ready to lead the charge in redefining biomedical data into groundbreaking insights? We are seeking a visionary Head of Translational Informatics to orchestrate our efforts in integrating multi-modal data for biomarker development, target discovery, and drug re-purposing strategies. As a key player in Alexion’s Bioinformatics and Data Sciences team, you'll drive innovation through AI/ML, bioinformatics, and real-world data applications. Join a high-impact team renowned for strategic value and collaboration across the organization. Your success will hinge on strong cross-functional partnerships, using diverse scientific expertise to deliver transformative insights.

Accountabilities:

• Lead the Translational Informatics function and craft a coordinated data strategy for biomarker discovery, patient stratification, and therapeutic insights.

• Collaborate with preclinical and clinical teams to translate omics, preclinical, and clinical data into actionable hypotheses.

• Craft and develop AI/ML models for target discovery/prioritization, drug re-purposing, and predictive analytics.

• Forge robust collaborations across research, clinical, regulatory, and commercial teams to align informatics strategies with business goals.

• Represent the company in external scientific forums and consortia to remain at the forefront of informatics and translational science.

• Stay abreast of scientific literature and integrate new insights into research activities and evaluation of new technologies and methods.

Essential Skills/Experience:

• PhD (or equivalent) in Bioinformatics, Computational Biology, AI/ML, Genomics, Systems Biology, Biomedical Informatics, or related field.

• Minimum 5 years of experience in pharma, biotech, or academia, with a focus on translational research and informatics.

• Solid understanding of human genetics, molecular biology, as well as biological pathways and networks.

• Deep expertise in AI/ML methods, particularly in biomedical data analysis and model interpretation.

• Experience in drug re-purposing using computational or integrative approaches.

• Hands-on experience working with multi-omics datasets, clinical trial data, and real-world data (RWD).

• Excellent communication and presentation skills with specific experience in cross-functional collaborations.

Desirable Skills/Experience:

• Prior involvement in rare diseases therapeutic areas is advantageous.

• Understanding of knowledge graphs, network biology, or causal inference is a plus.

• Experience working with clinical data, including data integration, curation, and analysis of patient-level datasets, is desirable.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from $133,970 to $200,954. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accorda