Engineer II, Upstream Viral Vector Product Development

This is what you will do: 

The Engineer II in the Upstream Process Development team will play a key role in the development of adeno-associated virus (AAV) production processes for gene therapy applications. This position involves working collaboratively with a multidisciplinary team to design, optimize, scale up, and tech transfer upstream processes involved in the production of viral vectors.  

You will be responsible for: 

• Support Upstream Development including the design and execution of laboratory experiments to develop and optimize upstream processes for AAV production, including cell culture, transfection, production, and harvest/lysis. 

• Troubleshoot process-related challenges and implement corrective actions to optimize production yields and maintain product quality. 

• Perform routine Upstream laboratory tasks such as shake flask and bioreactor sampling and cell maintenance. 

• Manage and maintain lab equipment and supplies, ensuring a safe and efficient work environment. This includes regular lab cleaning, equipment maintenance, and supply procurement.  

• Analyze and interpret experimental data, utilizing statistical tools to drive scientific decision-making and process improvements. 

• Collaborate with cross-functional teams including Downstream, Process Analytics, and Research.  

• Support the transfer of upstream processes to cGMP manufacturing. 

• Document experiments and results clearly and accurately in production files and electronic laboratory notebooks; Summarize and present results to the broader team. 

• Support the drafting of process development reports, process descriptions, and tech transfer documents.  

You will need to have: 

• BS or MS degree in Biomedical Engineering, Chemical Engineering, Biotechnology, or a related field 

• Minimum of 2+ years of relevant experience in the biotech industry 

• Hands-on experience with mammalian cell culture and aseptic technique 

• High level of proficiency in MS Office software 

• The duties of this role are generally conducted in a lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. 

We would prefer for you to have: 

• Experience with bioreactor set up and operation.  

• Experience with AAV or other viral vectors and transient transfection 

• Experience with statistical analysis and design of experiment (DOE) 

The annual base pay (or hourly rate of compensation) for this position ranges from $87,200 to $130,800. Our positions offer eligibility for variou