Senior Scientist, Investigative ADMET Laboratory

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Position Summary: 

The Investigative ADME, Toxicology and Bio-Analytical Research team focuses on drug discovery using innovative scientific approaches. We seek an experienced lab scientist to support and help develop our cross-site Investigative ADMET Laboratory capabilities, including playing a substantive role to design, build and deploy automation-friendly screening infrastructure. The candidate should have a passion and consistent track record for developing capacity enabling screening, mechanistic, investigative assays which deliver reliable results at the pace discovery research demands.  Strong collaboration with ADMET Project Leaders, lab-based scientists and medicinal chemists is essential. This role requires excellent people and communication skills, a positive attitude, willingness and agility to learn, attention to detail, and the ability to thrive in a fast-paced team environment.  The successful candidate will also be eager to apply emerging techniques in AI, agentic agents and automation to their laboratory work and results. 

Responsibilities: 

Maintain Safety in the workplace as a primary priority 

Design, implement, and interpret in vitro ADME assays (metabolic stability, protein binding, reaction phenotyping, CYP inhibition/induction, transporter studies) 

Develop and validate novel assays to predict in vivo outcomes and address DDI assessments 

Generate data for PBPK modeling and collaborate with medicinal chemistry 

Operate LC-MS/MS instrumentation (Sciex/Shimatzu platforms) for quantitative/qualitative analysis 

Partner with CROs to design studies and interpret outsourced data 

Present findings, author technical reports 

Minimum Qualifications 

• BS with 8+ years similar experience) within the pharmaceutical sector or related field. 

• Experience in vitro ADME assay design, execution, and interpretation 

• Experience with LC-MS/MS platforms and data analysis software (i.e. Sciex and Shimatzu platforms, Analyst software) 

Additional Preferences: 

• MS with 5+ years academic/research/industry experienceProven track record of delivering high-quality data in fast-paced, deadline-driven environments 

• Strong communication skills and ability to work effectively in cross-functiona