Sr. Associate Scientist II

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Background

RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC).  Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

Job Description

The laboratory-based role offers an opportunity to help advance novel Radiopharmaceutical therapies from laboratory into clinical testing. The candidate is responsible for developing and running biochemical and cell-based assays to support target validation, compound screening and mechanism of action studies for various pipeline projects.  The ideal candidate will be a critical thinker and a technical problem solver who enjoys working in interdisciplinary drug discovery teams. The role requires an ability and willingness to work with radioactive isotopes.

Job Responsibilities

Essential duties and responsibilities include the following.  Other duties may be assigned.

• Help develop and run biochemical and cell-based assays to support the screening, characterization, and lead-identification of novel RPT agents.
• Work with radioactivity in various assays in strict adherence to the radiation safety protocols.
• Work under the guidance of project team leaders to support the overall biology screening and evaluation plan, work closely with chemists, DMPK, imaging and in vivo teams to ensure implementation of screening funnel and appropriate prioritization of experiments.
• Generate, organize, and maintain meticulous records on all conducted experiments. Independently analyze and interpret data and present experimental plans and results at project team meetings, group meetings, and company meetings.
• Actively contribute to the experimental design and planning efforts to help achieve project goals under tight timelines.
• Collaborate with colleagues in other functional areas including translational research and chemistry.
• Assist in laboratory operation management duties.

Education and Experience

• BS with 4+ years of experience or MS 2+ years of experience within Biology, Biochemistry, Molecular Biology, or a related discipline with hands on laboratory experience.
• Prior experience of working on drug discovery projects in an industrial or an academic setting is preferred.

Skills

• Familiarity and hands on experience with invitro, cell-based assay development and optimization and proficiency with Cell culture, molecular biology techniques, ELISA, flow-cytometry, western blot, qPCR, single-cell cloning, immunohistochemistry and related protocols.
• Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.
• Strong interpersonal, organizational and communication skills
• Familiarity with drug development process and interfacing and working with interd