General Manager, US

Location: Remote

Reporting to: Chief Commercial Officer (CCO)

Job summary

The General Manager, U.S. will be responsible for the successful commercialization of products derived from Orchard Therapeutics’ unique HSC gene therapy platform in the U.S., starting with OTL-200 for the treatment of metachromatic leukodystrophy (MLD).

This individual is responsible for the development and operational execution of the commercial strategy for the U.S. market. The GM will be accountable for the region’s profit and loss (P&L) and for the direct management or oversight of the internal and external resources required to deliver outstanding results, aligned to both regional and corporate business goals.

This person will direct the U.S. Leadership Team (USLT) as well as participate on the Commercial Leadership Team (CLT) lead by the CCO.

Key Elements and Responsibilities

The successful candidate will be a highly strategic, inspirational leader with extensive experience in leading and driving high-performing commercial biopharma organizations. An exceptionally sharp thinker, this individual will bring strong analytical ability and a creative, solution-oriented style. S/he will be results orientated, driven, energetic, passionate about making a difference, flexible and able to work in a fast-paced, rapidly changing environment on multiple projects with aggressive deadlines and a certain level of ambiguity.

Requirements

Required knowledge

• General management experience preferred with responsibility for profit and loss
• Experience of recruiting, retaining, and developing specialized, high performing teams with cross-functional expertise (e.g., marketing, sales, reimbursement, patient services)
• Experience launching premium priced, rare disease products in the U.S. market, gene therapy experience preferred
• Experience in a fast paced, dynamic start-up biotech environment working across a matrix organization effectively and efficiently deploying limited resources
• A strong understanding of disciplines critical for the successful commercialization of biotechnology (e.g., marketing, sales, market access, reimbursement, patient services)

Skills & Abilities

• The ability to create and articulate an inspiring vision for the organization, not only for the areas s/he is directly responsible for, but also the enterprise as a whole
• The inclination to seek and analyze data from a variety of sources to support decision making and to align others with corporate strategy
• An entrepreneurial and creative approach to developing innovative ideas that will stretch the organization and be pioneering within the industry
• The ability to set clear and challenging goals while holding individual and teams accountability in driving results
• Comfortable with ambiguity and the ability to adapt nimbly to an ever-changing environment; the capacity to lead others through complex situations
• An ethical leader of character and a high degree of integrity; the ability to consistently act in a transparent manner taking into account what is best for the organization
• The ability to attract, recruit and develop top talent, motivate teams, delegate effectively, and manage performance
• The ability to persevere in the face of challenges, exhibit a steadfast resolve, and demonstrate a commitment to high standards
• A leader who is self-reflective, leads by example and drives performance with an attitude of continuous improvement
• Relationships and Influence
• An individual with the capability to build strong relationships with others, demonstrating high emotional intelligence and a knack for persuasively influence those with whom s/he has no direct managerial responsibility

Education

Bachelor’s degree in a related business or scientific discipline. MBA preferred.

Orchard Therapeutics is an Equal Opportunity, Affirmative Action employer. Minorities, women, veterans, and individuals with disabilities are encouraged to apply.