Staff Scientist I, Research Cores

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Overview
 

Are you passionate about translational biomedical research and scientific discovery? Interested in working in a dynamic, industry-inspired environment at the interface of academia and biotechnology? The Yale Center for Molecular Discovery (YCMD), a university-wide core facility within Yale School of Medicine, is seeking a highly motivated Staff Scientist I to support innovative research programs in high-throughput assay development, genomic screening, and early-stage drug and probe discovery.

YCMD provides investigators across Yale with access to specialized expertise in assay development, laboratory automation, chemical and genomic screening, and quantitative data analysis. The successful candidate will contribute intellectual and technical expertise to a diverse portfolio of projects spanning basic, translational, and therapeutic discovery research. Because YCMD supports a broad range of biological applications and disease areas, candidates with multidisciplinary scientific backgrounds and a strong interest in collaborative research are encouraged to apply.

The Staff Scientist I will:

• Lead and support high-throughput assay development and screening projects. Working independently and in collaboration with senior YCMD personnel, engage with investigators to define project goals and scope, evaluate experimental strategies, develop project plans, design and execute biochemical, cellular, and imaging-based assays, perform screening campaigns, analyze data, prepare reports, and recommend follow-up and validation studies.

• Maintain accurate and timely documentation of research activities. Present project updates at internal team meetings, communicate results to collaborators, prepare technical reports, and assist investigators in defining next-stage research objectives.

• Contribute to YCMD infrastructure development and daily laboratory operations. Operate, maintain, and troubleshoot advanced screening, automation, and imaging instrumentation; collaborate with vendors and service providers; and participate in technology evaluation, implementation, and process-improvement initiatives.

• Build and maintain productive relationships with investigators and collaborators within Yale and external organizations. Manage multiple concurrent projects while working effectively both independently and as part of multidisciplinary scientific teams. Contribute scientific data, analyses, and technical expertise to grant applications, publications, presentations, and other scholarly activities that advance the research mission of Yale University.

• Serve as a scientific resource for Yale researchers by providing expertise in high-throughput screening, assay development, genomic screening technologies, and approaches to chemical and genetic probe discovery. Participate in training, educational, and mentorship activities supported by the Center.

Required Skills and Abilities

1. Demonstrated ability to work independently and collaboratively within multidisciplinary teams to support and manage scientific projects, develop experimental strategies, and execute complex research programs.

2. Ability to quickly learn and implement new technologies and methodologies.

3. Excellent organizational, communication, and interpersonal skills, with the ability to prioritize competing demands and effectively manage multiple concurrent research and infrastructure projects.

4. Strong foundation in molecular biology, cell biology, and related biomedical disciplines.

5. Strong analytical and problem-solving skills with the ability to interpret experimental data, troubleshoot technical challenges, and communicate scientific findings.

Preferred Skills and Abilities

1. M.S. degree in Biology, Biochemistry, Molecular Biology, Pharmacology, Biomedical Sciences, or a related field, with at least two years of research experience in an academic, biotechnology, or pharmaceutical setting.

2. Proven experience working in a research core facility, shared-resource environment, contract research organization (CRO), or similar service-oriented scientific setting.

3. Proven experience with laboratory automation, liquid handling systems, high throughput screening (HTS), genomic screening technologies, recombinant protein production and characterization, microscopy, and image analysis workflows.

4. Proven experience applying statistical and computational approaches to the analysis