Senior Scientist I, Toxicology

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

In anticipation of the Company’s growth plans, we are seeking a Toxicologist to lead safety strategies for small molecule discovery programs and work in close collaboration with colleagues across our Research and Development organizations to enable the advancement of portfolio programs. The ideal candidate will deliver a balanced assessment of the risk/benefit profile of drug candidates by integrating pharmacology/toxicology studies and engaging with stakeholders to align on tractable clinical development strategies. Further, the ideal candidate will:

• Function as a project toxicologist on drug discovery and development project teams and be a strong advocate for patient safety.

  • Design and oversee nonclinical toxicology programs to advance pipeline of small molecule cancer therapeutics by implementing target de-risking, screening, in vivo testing strategies, issue mitigation, and investigation of toxicities.

• Assess new technologies to support/improve compound toxicity prediction & screening, and development of translational/safety biomarkers.

  • Oversee exploratory in vitro, ex vivo and/or in vivo studies that focus on understanding underlying biological and/or chemical mechanisms of toxicity.

  • Partner with internal and external collaborators and stake-holders related to integrated large-scale data analytics, computational and chemical mining efforts.

• Effectively implement and oversee studies outsourced to CROs, in collaboration with RevMed study operations, pharmacology, DMPK and clinical pharmacology functions.

• Analyze, interpret, and summarize nonclinical safety data, and present and contextualize meaningful findings with recommendations to internal project teams and RevMed leadership.

• Ensure timely and accurate nonclinical study deliverables of projects to enable compound progression and decision-making, including drafting and review of nonclinical sections of regulatory documents.

Required Skills, Experience and Education:

• Ph.D. degree in toxicology, pharmacology or related discipline with 3+ years of relevant biotech/pharma drug discovery/development experience in a team-facing role.

• Strong scientific background and scientific aptitude, with excellent critical thinking and problem-solving skills.

• Ability to work effectively and collaboratively on cross-functional project teams; demonstrated ability to multitask, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.

• Familiarity with GLPs and FDA/ICH guidance documents for nonclinical toxicology/safety pharmacology regulatory submissions.

• Excellent verbal, oral and written communication skills.

• Thrives in a collaborative team setting and is driven by a desire to be innovative in a high energy, small company environment.

Preferred Skills:

• Experience working with small molecules and targeted oncology therapeutics of all modalities.

• Experience preparing nonclinical safety sections supporting submissions (e.g. IND/NDA, IB, DSUR). #LI-Hybrid #LI-CT1

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion,