Senior Scientist--In Situ Biology

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

POSITION SUMMARY

As a member of our ADC Discovery team, you will perform spatial biology experiments to validate targets for antibody-based therapeutics, as well as explore their effects on the tumor microenvironment. You will serve as a histopathology/immunohistochemistry subject matter expert, representing the In Situ Biology sub-team and communicating findings to interdisciplinary project teams.

RESPONSIBILITIES

• Independently design, execute, and interpret experiments aimed at understanding the spatial context of target expression in tumor and normal tissues.

• Work with project teams, management, pathologists, and peers within the Oncology Research Unit to ensure studies are aligned with project goals and best experimental practices.

• Communicate with project teams to ensure executed studies satisfy intended goals and results are interpreted appropriately.

• Present findings to project teams, leadership, and interdepartmental meetings.

• Represent the In Situ Biology sub-team on project teams as a histopathology/immunohistochemistry subject matter expert and contribute to scientific discussions.

• Evaluate, propose, and implement new procedures in step with advancing industry and academic standards.

• Create reports, contribute to internal and external presentations and journal articles, and diligently record experiments in laboratory notebooks.

MINIMUM REQUIREMENTS – Must Have

• Recent PhD in a biological science related discipline OR

• MS in a biological science related discipline with 7 years of experience with histopathology techniques OR

• BS in a biological science related discipline with 9 years of experience with histopathology techniques.

• IHC and ISH assay development expertise.

• Experience with advanced histology methodologies, including multiplex immunohistochemistry and in situ hybridization

• An understanding of tumor biology.

• Experience working collaboratively in a cross-functional research environment.

• Experience handling multiple projects simultaneously.

• Strong communication skills—verbal, written, and presentation.

• Proficiency using laboratory notebooks and whole slide imaging using digital scanners.

• Proficiency with Microsoft Office software including Excel and PowerPoint, and analysis software like GraphPad Prism or Spotfire.

NICE TO HAVE

• Experience with digital image analysis tools such as HALO and/or Visiopharm.

• Experience with core histology methodologies, such as processing, embedding, and sectioning.

• Experience and interest in mentoring and leading colleagues.

  

PHYSICAL/MENTAL REQUIREMENTS

• Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Occasional travel to other Pfizer sites for internal meetings or to external conferences.

Relocation support available

Work Location Assignment: On Premise

The annual base salary for this position ranges from $93,600.00 to $151,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are a