Senior Principal Scientist, Cellular Pharmacology and Lead Discovery

Job Description

Our Research Laboratories in South San Francisco is seeking a highly experienced and innovative cell pharmacologist with extensive drug discovery expertise in cardiovascular and metabolic diseases to join our Quantitative Biosciences (Pharmacology) department. The successful candidate will have direct line management of a research team responsible for the design, execution, and interpretation of complex in vitro/ex vivo assays as well as mechanistic experimentation to advance drug discovery from target concept through lead optimization. The candidate will also work closely with therapeutic area stakeholders, chemists, protein scientists, and multidisciplinary quantitative scientists to define strategies for target validation, screening, assays/models, and critical studies to advance a diverse portfolio of small molecule and biologic preclinical candidates targeting metabolic dysfunction and complications, obesity, heart failure, and other related disorders. In addition, this role will participate in business development due diligence and establish strategic internal and external partnerships to drive portfolio development and progression. If you are a highly motivated leader and team player with a proven tracker record of success in driving cardiometabolic drug discovery, we invite you to consider joining our team.

Key responsibilities:

• Develop and support comprehensive pharmacology strategies targeting obesity, immuno-metabolic, and cardiovascular diseases to enable a robust drug discovery pipeline

• Drive hit/lead finding and lead optimization plans in collaboration with therapeutic area stakeholders, Chemistry, Biologics, and multidisciplinary teams

• Lead the development and implementation of potency, selectivity, and mechanistic assays to characterize molecules targeting diverse targets and areas of biology

• Lead the design and execution of complex models utilizing physiologically relevant cellular systems and advanced technologies

• Serve as a core member in matrixed project teams and governance committees to guide pharmacology strategy and provide scientific and technical leadership

• Ensure high-quality data generation, analysis, and reporting to project teams, governance bodies, and regulatory agencies, and manage key timelines and milestones

• Lead and develop a group of PhD and non-PhD researchers, drive scientific innovation, and champion new enabling technologies to enhance functional capability and productivity

• Monitor emerging biology, biomarker, as well as basic & clinical research in cardiometabolic disorders to influence portfolio development strategy

• Collaborate extensively across our network and with external partners to drive pipeline progression toward key milestones

Qualifications:

Education:

• Ph.D. in Pharmacology, Cell Biology, Immunology or related discipline and relevant industry experience listed below

Required Experience and Skills:

• A minimum of 15 years of drug discovery experience at a biotech or pharmaceutical setting in obesity, dysmetabolism, diabetes and cardiovascular complications, with demonstrated quantitative pharmacology expertise

• Proficiency in drug discovery strategies and processes throughout target identification and validation, lead optimization, preclinical candidate selection, and early development

• Highly skilled in complex cell-based assays/models for biomarker discovery and translation, utilization of lab automation, and deep expertise in mechanistic pharmacology

• Experience leading discovery teams, setting strategy & priorities, and managing resources

• An excellent track record of providing mentorship to direct reports and influencing peers

• Ability to work collaboratively in a cross-functional team environment to shape strategy and tactics and drive rapid pipeline progression toward key milestones

• Solid data science and analytical skills, as well as excellent written and oral communication

• A strong record of publication in peer-reviewed journals and/or patent literatures

Preferred Experience and Skills:

• Expertise in physiologically relevant cell models (primary cells, complex co-culture, 3D, microfluidics, etc.) and translational assays

• Prior experience working with multiple therapeutic modalities (small molecule, peptide, biologic, etc.)

NOTICE FOR INTERNAL APPLICANTS

In accordance with