Associate Scientist/Scientist in Structural Biology – Fontana Lab, Center of Excellence for Pediatric Immuno-Oncology
St. Jude Children's Research HospitalAbout the role
Dr. Pietro Fontana, Assistant Member in the Center of Excellence for Pediatric Immuno-Oncology (CEPIO) and the Department of Immunology, is seeking a curious, motivated structural biologist to join our team as either an Associate Scientist or Scientist.
The Fontana lab focuses on understanding how immune receptors recognize danger signals and initiate downstream responses, with a particular emphasis on the mechanistic basis of activation and small molecule modulation. We investigate pathways involving cytosolic DNA sensors, inflammasome components, and adaptor proteins such as cGAS, AIM2, and TLRs. Our research integrates cryo-EM, cell biology, and chemical biology to dissect how molecular architecture governs immune function. Recent work includes the discovery and structural characterization of novel dsDNA sensors and the identification of small molecules targeting key innate immune components https://doi.org/10.1016/j.cell.2024.08.007.
This is more than just a role — it’s a chance to contribute to discoveries that could transform how we understand immunity and develop therapies for some of the toughest pediatric cancers.
What You’ll Do
Express and purify immune signaling proteins and complexes in multiple systems (bacterial, insect, mammalian).
Prepare samples for structural studies by cryo-electron microscopy (cryo-EM) and/or X-ray crystallography.
Perform data processing and model building (e.g., Relion, CryoSPARC, Coot, PyMOL).
Design, troubleshoot, and carry out experiments in partnership with a collaborative team.
Keep projects moving by coordinating lab activities and supporting shared equipment.
Contribute your insights to manuscripts, presentations, and ongoing brainstorming to push our science forward.
Mentor junior lab members and help foster a positive, ambitious lab culture.
What We’re Looking For
We welcome candidates with a strong background in structural biology who are excited to apply their skills to immunology. Our ideal teammate will have:
Hands-on experience with protein expression, purification, and biochemical characterization using bacterial, insect, or mammalian systems.
A good working knowledge of cryo-EM pipelines and data processing.
Prior knowledge of basic cell culture, and cell-based assays
A collaborative spirit, adaptability, and a genuine curiosity to learn new approaches.
We also value enthusiasm, teamwork, and creativity — whatever skills you haven’t mastered yet, we’re eager to help you grow.
Scientist: Minimum Education and/or Training:
Eight (8) years of relevant work experience is required
Six (6) years of relevant work experience is required with a Master's degree
Three (3) years of relevant work experience is required with a PhD
Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred
Experience in guiding and training other laboratory personnel preferred
Proven performance in earlier role/comparable role
Associate Scientist: Minimum Education and/or Training:
7 + years of research experience is required
5 + years of research experience is required with a Master’s degree
2 + years of research experience is required with a PHD
Experience leading and supporting research experiments preferred
Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred
Experience in guiding and training other laboratory personnel preferred
Proven performance in earlier role/comparable role
Apply for this role
Generate a tailored application kit with a matched cover letter, interview prep, and CV highlights — in under 60 seconds.
Apply Now →Generate Application KitFree account required — sign up in 30s