Senior Director, Lab-to-Product Platform and Operations Technology

Overview

Alnylam is seeking a strategic and pragmatic technology leader to serve as Senior Director, Lab-to-Product Platform & Operations Technology, a role that owns the core digital platforms, services, lab computing environment, and operational technologies that power laboratory operations across Research, CMC, and Quality Control, as well as digital enablement of plant-floor (shopfloor) operational technologies (OT).

This scope extends beyond internal operations to include operational technology enablement, secure data exchange, workflow interoperability, and validated system readiness that support external execution partners—including CROs, external research labs, development collaborators, contract testing labs, and external manufacturing partners.

This role is focused on operational platforms—the systems, integrations, partner connectivity, validated interfaces, computing environments, and services that ensure labs,  plants, and external partners run reliably, compliantly, and efficiently. Scientific research platforms and enterprise manufacturing systems (e.g., MES and supply chain planning) are owned by their respective teams. This role ensures seamless interoperability, operational data flow, OT enablement, and validated integration frameworks across internal and external environments while maintaining clear ownership boundaries.

This role is responsible for building and operating a modern Lab-to-Product operational platform that connects experiment execution, sample and materials workflows, QC testing, and plant operations – regardless of whether those activities occur internally or through external partners.

This hybrid role is based primarily in Cambridge, MA, with regular engagement at our Cambridge labs and Norton/Alewife manufacturing sites, and direct interaction with external execution partners.

Key Responsibilities

1. Own and operate core lab, plant, and external partner operational platforms

• Lead the digital capabilities that support lab operations across Research, CMC, and QC, including LIMS, ELN/LES, sample & inventory management, registration, lab automation enablement, instrument integration, lab computing, lab system validation, and operational data capture.
• Oversee plant-floor operational technologies (OT) such as equipment/instrument connectivity, environmental and facility monitoring interfaces, materials tracking, barcode/RFID data capture, and automated data collection (excluding MES and supply chain systems).
• Enable operational technology connectivity, workflow interoperability, and validated data exchange with CROs, external research labs, development partners, contract testing labs, and external manufacturers.
• Support validated data handoffs, sample/material traceability, workflow tracking, and operational interfaces across hybrid (internal + external) execution models.
• Ensure reliability, compliance, validated state, lifecycle management, and service continuity across internal systems and partner-connected operational interfaces.
• Oversee lab/operational system validation activities in partnership with Quality to maintain GxP compliance and data integrity across all execution environments.

2. Build the Lab-to-Product Platform (Internal + External Execution Model)

• Architect and deliver the operational platform that connects experiment execution → sample workflows → QC testing → plant operational activities → external execution and release workflows.
• Provide reusable platform components including metadata standards, workflow modules, instrument connectors, validated integration frameworks, and operational data pipelines that external partners can adopt or interface with.
• Ensure seamless interoperability with:
  • Scientific platforms owned by ReDev Technology
  • Manufacturing/enterprise systems owned by Manufacturing/CMC/Supply Chain Technology
  • External research, development, QC, and manufacturing partner systems
• Establish secure, scalable, validated patterns for partner connectivity (e.g., APIs, secure file exchange, partner portals, event/data streams).

3. Lead a high-performing operations-focused technology team

• Build and develop talent and capabilities across product management, engineering/architecture, lab computing support