UNIV - Research Specialist II - Department of Pharmacology and Immunology

Job Description Summary

A Research Specialist II is needed for studies on characterizing nanotubes for drug delivery into the brain. Tasks may involve one or more of the following: preparing nanotubes of defined length for use in in vitro blood-brain barrier (BBB) transit and for BBB transit in mice. Mouse studies will be carried out in collaboration with the Small Animal Imaging Shared Resource at Hollings Cancer Center. This is an exciting opportunity to develop a groundbreaking technology for drug delivery across the BBB.
executing data analysis on new software, cell culture, cell assays such as migration, invasion proliferation, western blotting, microscopy, tissue preparation, ELISAs, proteomics, data analysis

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type​

Research Grant

Cost Center

CC001032 COM PHARM Administration CC

Pay Rate Type

Hourly

Pay Grade

University-05

Pay Range

38,985.00 - 55,559.50 - 72,134.000

Scheduled Weekly Hours

40

Work Shift

Job Description

• 25% Lab Setup and Management: Assist the principal investigator in establishing an efficient lab that fosters scientific discovery and training. This includes managing lab operations such as ordering supplies and organizing lab activities, while contributing to a collaborative and supportive work environment.

• 30% Molecular and Cellular Assays: Prepare nanotubes and develop a standard operating procedure enabling production scale-up. Monitoring of nanotube assembly will be monitored by confocal microscopy. Set-up and use of an in vitro cell-based model of the BBB is required for initial testing of nanotubes.

• 20• % Loading nanotubes with small molecule drugs or biologics (mAbs) during assembly will also be required. Labeling of nanotubes with fluorescent or infra-red dyes to allow monitoring their shuttling across the BBB in mice is required.

• 15% Contribute to the planning, design, manuscript writing, grant applications, regulatory documentation, and modification of experiments.

• 10% Maintain a detailed notebook of experiments performed and location of where data is stored. This requires use of an electronic research notebook platform (LabArchives). Organizing and participating in lab meetings, present research findings, and contribute to scientific discussions.

Additional Job Description

Minimum Requirements: A bachelor's degree in chemistry, biology, or other natural, life or health care science and one year work experience directly related to the assigned research area. Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Frequent) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb, using step stool. (Infrequent) Ability to work in temperature extremes (32° F to 100° F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent) Ability to work in confined/cramped spaces. (Continuous) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent) Ability to fully use both legs. (Frequent) Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent) Ability to maintain good olfactory sensory function/distinction. (Continuous) Ability to lift materials up to 20 lbs., unassisted. (Infrequent) Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent) Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent) Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/ Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent) Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent) Ability to push/pull file boxes from one location to another at floor level. (Frequent) Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to maintain 20/40 vision, corrected, in one eye or with both eyes. (Continuous) Ability to match or discriminate between colors, normally. (Continuous