Research Assistant / Research Scientist – Bioanalytical

POSITION TITLE: Research Assistant / Research Scientist – Bioanalytical

ABOUT US

Calibr, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Calibr was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities.  Scripps Research is ranked one of the most influential institutions in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Calibr has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Calibr’s drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age-related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team.

Position Overview

The Calibr Bioanalytical team is seeking a highly motivated individual to support pharmacology in our drug discovery efforts. Under this role, the ideal candidate will work to develop LC-MS assays for novel compounds to support key ADME and pharmacokinetic assays and assist in developing new ADME assays to increase internal bioanalytical capabilities. The individual would work in support of multiple drug discovery programs that encompass multiple modalities such as small molecule, peptide, protein, and antibody therapeutics.

Essential Duties and Responsibilities

• Sample preparation from biological matrices, tissue homogenization, and method development
• Develop methods for of quantitation of NMEs using LC-MS in support of drug discovery programs
• Perform routine LC-MS instrument maintenance, as well as develop and trouble-shoot LC-MS methods
• Data analysis and lab notebook documentation
• Maintain databases and perform routine lab maintenance functions
• Author bioanalytical reports and present findings to research teams
• Perform QC analysis of external CRO PK and ADME reports  
• The position requires great attention to detail, troubleshooting capability and flexibility to adapt to a fast-paced environment
• Details of established essential functions for this position will be addressed/discussed during the interview process.

 Qualifications and Experience

• Bachelor or Master of Science in biology, chemistry, biochemistry, or related field
• Minimum 1 year of laboratory experience required; 3+ years of experience preferred
• Experience with LC-MS and method development
• Experience with database interface and data analysis software (ie. Excel & Prism)
• Experience with WinNonlin and/or GastroPlus desired
• Excellent oral and written communications skills
• References required

Physical Demands and Work Environment

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions.

COMPENSATION

The expected hiring range for this multi-level position is $66,560 - $79,500, commensurate with experience. Consideration will be given to experience that exceeds the listed requirements. 

COMPREHENSIVE BENEFITS INCLUDE:

• Eligibility for retirement plans with employer contribution.
• Full suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more.
• Access to Flexible Spending Accounts (Medical/Dependent Care).
• Competitive vacation and sick leave policies.
• Free, on-site Counseling Center which provides confidential counseling services to benefits-eligible employees and their family members.
• Free, on-site parking. 

The above statements describe the level of work performed and expected in general terms.  The statements are not intended to list all the responsibilities, duties and/or skills re