Senior Scientist, Protein Analytical Characterization

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

Discovery Biotherapeutics and Genetic Medicine (BGM) at AbbVie is seeking a highly motivated and experienced scientist to join the Protein Sciences Analytical Team in Worcester, MA. This position provides a unique opportunity to directly impact multiple Discovery Research Therapeutic Areas (TAs) and projects by delivering in-depth analytical and functional characterization of biologics and biopharmaceutical products—including complex protein antigens, monoclonal antibodies, multi-specifics, and other antibody-like biologics. The ideal candidate will have a strong background in protein analytical characterization, with expertise in structural mass spectrometry, including hydrogen-deuterium exchange mass spectrometry (HDX-MS), crosslinking mass spectrometry (XL-MS), and covalent labeling mass spectrometry (CL-MS) to characterize epitopes and antigen-antibody interactions. The successful candidate will foster productive collaborations across functional groups and therapeutic areas. This is an excellent opportunity for a motivated scientist to make a significant impact in a collaborative and innovative environment. Join us in bringing innovative medicines to patients!

Key Responsibilities:

• Independently develop and execute high-throughput HDX-MS workflows for epitope mapping analysis of biotherapeutics to support discovery pipeline projects.
• Develop, optimize, validate, and apply innovative structural MS methods (including XL-MS and CL-MS) to characterize epitopes and antigen-antibody interactions.
• Demonstrate scientific initiative and creativity by establishing novel workflows and strategies for the characterization and screening of biologics—including non-traditional modalities such a