Company Overview:

Dyne Therapeutics is discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE™ platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. For more information, please visit https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook. 

Role Overview:

The Head of Portfolio Strategy and Operations (PS&O) drives successful delivery of key corporate objectives by ensuring the robust development of portfolio and program strategy and effective translation of strategy into integrated planning and timely operational execution across Dyne. The Head of PS&O reports into the Chief Executive Officer (CEO) and is a member of the Dyne Executive Committee (EC).

The Head of PS&O oversees Program Leadership, Program Management and Clinical Operations at Dyne by managing, coaching and guiding the Head of Clin Ops, Head of PM and the Program Team Leaders to enable exceptional performance of cross-functional Program Teams and clinical studies across the Dyne portfolio:

• Leads high-performing team of Program Team Leaders, driving the articulation of program strategy, vision, goals and priorities, bringing both a 'future- orientation' toward the ultimate goal of broad, global commercial access for patients in need, and a "pragmatic-orientation" to chart the path, mitigate risks, cultivate options, and lead the company through complex drug development decisions
• Oversees high-performing team of Program Managers, including direct management of the VP, Head of Program Management; driving achievement of company and program goals and the advancement of the company’s portfolio of programs ensuring effective cross-functional contributions from all company functions
• Oversees high-performing Clinical Operations team, including direct management of the VP, Head of Clinical Operations, and overall accountability for team based in US and EU; drives exceptional planning, start-up, conduct and close-out of Dyne clinical studies in line with corporate goals
• Articulates and drives the vision for how to build and scale the PTL, PM and Clin Ops organizations, capabilities, processes and infrastructure to support Dyne future growth

As a member of Dyne Executive Committee, the Head of PS&O partners with Dyne executive leadership team to integrate and harmonize Business Operations across the organization, driving portfolio level cross-program and cross-functional integration, coordination and operations across Dyne:

• Oversees Dyne governance, partnering with executive leadership to ensure timely, high-quality and cross-functional decision-making and information sharing to enable advancement of Dyne portfolio and programs
• Partners on the Dyne strategic planning process with CFO, ensuring development of robust program and project long- and short-range plans in line with corporate goals and resources
• Partners with CMO to build out integrated Development Operations capabilities to enable growth of late-stage development programs and the expansion of Dyne’s clinical pipeline.
• Oversees development of non-program operations to ensure harmonization and alignment of project management discipline and methodology across organization

Key Responsibilities of the Role: 

• Lead and develop team of Program Team Leaders and Program Managers to effectively advance Dyne Programs and foster seamless integration and communication across the company:
  • Drive understanding and inspire the big picture thinking of corporate, portfolio and program strategy and cross-functional interdependencies in order to lead execution across all Programs
  • Partner with Program Team Leaders to provide strategic and operational leadership to programs to achieve Program and company goal

• Ensure effective partnership with cross-functional representatives to develop comprehensive product development, commercialization and lifecycle management plans that optimize: value, time, resources, risk, and alignment with business objectives
• Oversee and enable high-performing cross-functional Program Teams, focusing on both the "what", such as strategy, priorities, output, and resources, and also the "how", suc