Director, Translational Sciences, Translational Research

The Opportunity:

As Director, Translational Sciences, you will be a key member of Translational Research, reporting to the Vice President of Translational Research focusing on:

• Lead the scientific strategy and execution of the Translational Research Assay Core, ensuring delivery of high-quality, innovative assays supporting discovery and translational programs.

• Establish and continuously evolve assay platforms that enable biomarker discovery, pharmacodynamic assessments, mechanism-of-action studies, and translational hypothesis testing.

• Drive exploratory translational research aimed at understanding mechanisms of sensitivity, intrinsic resistance, and acquired resistance across the Revolution Medicines portfolio.

• Develop and execute mechanistic studies using patient-derived samples, preclinical models, and emerging technologies to generate actionable biological insights.

• Identify novel therapeutic vulnerabilities and rational combination strategies based on clinical and preclinical findings.

• Translate observations from clinical studies into research hypotheses that inform target discovery, drug discovery, and translational strategies.

• Foster seamless bidirectional translation between clinical observations and discovery research.

• Apply functional genomics, single-cell and spatial approaches, and complementary molecular and cellular methods to generate decision-enabling data.

• Partner with computational scientists to integrate multi-omic datasets with functional biology and generate mechanistic insights.

• Cross-functional Leadership: Partner across Research, Translational Medicine, Bioinformatics, and Clinical Development to integrate findings into biomarker and development strategies.

Responsibilities

• Scientific Leadership & Execution: Design, prioritize, and interpret rigorous studies using clinically relevant models and patient-derived materials to address key translational questions.

• Reverse Translation & Resistance Biology: Convert patterns of response, non-response, and progression into experimental studies that define mechanisms and inform novel therapeutic targets and/or combination strategies.

• Data Integration: Integrate experimental results with clinical, biomarker, and computational datasets to generate actionable insights.

• Capability Building: Establish and evolve internal workflows, evaluate new technologies, mentor scientists, and manage external research partners as needed.

Required Skills, Experience & Education:

• PhD, MD, or equivalent advanced degree in cancer biology, molecular or cellular biology, biological engineering, translational sciences, or a related discipline, with 10+ years of relevant experience.

• Deep expertise in oncology biology and demonstrated success connecting human disease or clinical observations to experimental models and drug-development hypotheses.

• Strong knowledge of targeted therapy, oncogenic signaling, and mechanisms of drug response and resistance; experience in RAS-driven cancers is highly desirable.

• Experience with functional genomics and high-dimensional profiling technologies, including single-cell, spatial, or integrated multiomic approaches.

• Proven ability to lead cross-functional research, influence strategy, and communicate clear, decision-oriented recommendations.

Preferred Skills:

• Experience establishing or scaling laboratory-based reverse translation or translational research capabilities in biotechnology or pharmaceutical settings.

• Hands-on experience with patient-derived specimens or models, perturbational studies, and validation of biomarkers or resistance mechanisms.

• Breadth across tumor-intrinsic and tumor-microenvironment biology and experience integrating ex