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Senior Staff or Principal Software Engineer, Rust Genomics Infrastructure

St. Jude Children's Research Hospital
United Statesfull_timeVerifiedPosted 13 Jan 2026
💰 $238,160/yr($125,840/yr$238,160/yr)

About the role

The Principal Software Engineer anticipates, identifies, and provides solutions for complex problems through deep technical analysis.

Project Description:

St. Jude is seeking a seasoned Rust developer to lead the development of software to facilitate genomics analysis at scale. Foundationally, this position will work on writing (or rewriting) tools that underpin the genomics ecosystem in Rust. This position requires a deep understanding of the Rust programming language and agility working with the core concepts therein, proficiency in algorithm development with a focus on optimization via profiling, and a track record of developing software with strong documentation and testing. A portion of this position’s time will be dedicated to open-source software development: for these projects, active community management and engagement are vital to ensuring adoption of these tools. Beyond engineering, both synchronous and asynchronous communication skills—particularly in the areas of ideating on project direction, tracking project progress, and overall engagement with the community of these tools—are critical to ensuring success of the project. Of note, specific experience with bioinformatics and genomics is not required; we’re targeting talented software engineers who want to expand into the fields of bioinformatics and genomics (visit https://learngenomics.dev/ to learn more about genomics in the context of software engineering).


About St. Jude:

There’s a reason St. Jude Children’s Research Hospital consistently earns a Glassdoor Employee Choice Award and is named to its "Best Place to Work" list. At our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve. There is a unique bond when you are part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support, and encouragement to advance and grow their careers.

About Memphis:

This position is based in Memphis, TN; relocation assistance is available. Memphis is a family-friendly metropolitan area where more than a million residents call home. Memphis is recognized for its world-class music, food, and hospitality. Cost of living is one of our biggest attractions; in fact, Money listed Memphis as one of the least expensive cities in which to raise a child. Mild winters and beautiful green spaces make the city a magnet for outdoor enthusiasts – there are over 200 miles of bike-friendly lanes with more being added. Forbes recently named Memphis the 4th happiest city in which to work. Why live anywhere else?

Principal Software Engineer Job Responsibilities:

  • Anticipate problems and opportunities in the scientific domain; advocate for strategic plans based on deep technical and scientific knowledge
  • Independently perform deep analysis of scientific data to identify problems and opportunities for improvement.
  • Mentor junior staff in technical and scientific concepts and actively contribute to local body of knowledge.
  • As part of a multi-disciplinary team, identify technical solutions to complex scientific problems and lead the implementation of those solutions.
  • Serve as a technology advocate and technical thought leader within the assigned area, inspiring productive change through technology solutions, guiding application strategy, and providing recommendations for future development.
  • Prepare scientific manuscripts and presentations.
  • Perform other duties as assigned to meet the goals and objectives of the department and institution.
  • Maintains regular and predictable attendance.

Minimum Education and/or Training:

  • Bachelor's degree in computer science, data science, information science, business, or related field required.
  • Master's degree preferred.

Minimum Experience:

  • Minimum Requirement: Bachelor's degree with 12+ years of relevant experience.
  • Experience Exception: Master's degree with 10+ years of relevant experience.
  • Experience with programming languages, databases, and software development lifecycle.
  • Significant experience within the technical and/or scientific domain required.
  • Proven leadership in earlier role/comparable role.

The Senior Software Engineer develops software used in big data analysis as part of a team of scientists and engineers at the forefront of research into catastrophic childhood disease. Provides solutions through a combination of implementing/modifyin

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Company

St. Jude Children's Research Hospital

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