Senior Director, Medical Science Liaison

Madrigal is a biopharmaceutical company pursuing novel therapeutics for non-alcoholic steatohepatitis (NASH), also known as metabolic dysfunction associated steatohepatitis (MASH). Our first therapy, Rezdiffra (resmetirom), was granted accelerated approval by the U.S. Food and Drug Administration (FDA) for the treatment of adults with NASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) and is being studied in a Phase 3 trial for the treatment of NASH with compensated cirrhosis.

 Title: Sr. Director, Medical Science Liaison (MSL)       

Region: West, Central, Northeast, Southeast 

 
Role Summary 

The Sr. Director, Medical Science Liaison (MSL) is a key field-based leadership position responsible for the strategic and tactical oversight of the MSL team within a defined U.S. region. This individual will play a critical role in managing and developing MSLs, ensuring the team executes against the company’s medical strategy, complies with regulatory and internal policies, and delivers scientific value to both internal and external stakeholders. 

This position will interface regularly and compliantly with cross-functional colleagues (e.g., Marketing, Sales, Market Access, Clinical Operations, HQ Medical Affairs) and external partners, including Thought Leaders (TL), healthcare decision-makers, and other relevant stakeholders. 

Key Responsibilities 

• Team Leadership & Development 

• Recruit, coach, and manage performance of regional MSLs 

• Foster continuous development through mentoring and training 

• Align MSL activities with strategic objectives and tactical plans 

• Medical Strategy Execution 

• Drive implementation of regional field medical strategies 

• Translate national objectives into actionable, regionally tailored activities 

• Partner with cross-functional teams to integrate field insights into medical planning 

• Cross-functional Collaboration 

• Collaborate closely with Sales, Marketing, Market Access, and Clinical Operations 

• Serve as a field-based liaison for HQ Medical Affairs initiatives 

• Contribute to launch readiness and lifecycle management strategies 

• Clinical Trial Support 

• Collaborate with Clinical Operations to ensure successful study execution based upon recognized needs 

• Congress & External Engagement 

• Represent Medical Affairs at U.S. medical congresses in a compliant manner 

• Coordinate booth planning, scientific exchange, competitive intelligence, and post-conference debriefs 

• Strategic Team Building 

• Contribute to the design and structure of the U.S. Field Medical team 

• Identify evolving business needs and adjust regional capabilities accordingly 

• Compliance & Quality 

• Ensure all MSL activities comply with company SOPs, industry standards, and applicable regulations 

• Uphold the highest ethical standards in all external engagements 

• Travel Requirement 

• Willingness to travel 25–75% for congresses, site visits, and stakeholder engagement 

Qualifications & Experience 

• Advanced degree in a scientific or healthcare discipline (MD, PharmD, PhD, DNP, etc.) 

• Minimum 5 years of Medical Affairs experience, including at least 3 years as an MSL or equivalent (translatable clinical practice experience will be considered)  

• Minimum 3 years of people management experience or formal leadership development participation 

• In-depth knowledge of clinical medicine and medical research; experience in cardiometabolic health, or MASH/NASH preferred