Senior Research Associate, Preclinical Development

We are seeking an experienced Senior Research Associate to evaluate novel genome editing systems for in vivo therapeutics as a member of our growing pre-clinical research team. Reporting to an Associate Director and Project Team Lead, you will support the design and execution of assays to advance and validate a gene editing therapeutic program and will play a key role in vitro modeling for gene editing. This position contributes to characterization of a therapeutic target as well as the effects of gene editing in both cells and animal models. The successful candidate will have experience with cell line maintenance and cell and molecular assays. This role will be based in Emeryville, California.

How you’ll contribute: 

• Culture diverse types of cells ranging from primary human cells to mouse and cyno cell lines.
• Perform genome-editing experiments by transfecting cells using various methods 
• Purify DNA, RNA and protein from cultured cells and animal samples 
• Routinely assess genome-editing by performing molecular analysis of DNA and RNA (qPCR, ddPCR, NGS), and protein samples (Western blot, ELISA, activity assays).
• Prepare accurate and timely data summaries and contribute to the writing of reports.
• Generate and analyze experimental data under the direction of an Associate Director and present this data in team and departmental meetings.
• Collaborate with research and other functions to optimize and advance assays and experiments to validate and analyze results and advance therapies

What you bring:

• BS or MS in biology, biochemistry, genetics, molecular biology, or a related discipline
• At least four years of relevant research laboratory experience in either academia or industry applying molecular biology skill sets. 
• Hands-on experience with culture of mammalian cell lines, primary cells and iPSCs.
• Hands-on experience in microscopy and imaging, gene expression assays (ddPCR, qPCR, RNAseq), as well as western blotting and ELISA.
• Experience with genome editing techniques and analysis  is a plus
• Effective oral and written communication skills
• Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities
• Highly collaborative, team-oriented, and considerate of the needs of others
• Thrives in a fast-moving, results-oriented startup environment with urgent deadlines
• Independent and self-sufficient, but knows when to ask questions or seek support
• Self-motivated, passionate about your work, and eager to continuously learn more

California Pay Transparency Disclosure:

This position is classified as an exempt position under the Federal Labor Standards Act.  The anticipated base salary range for this position will be $100,000 - $115,000  You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education. 

About Metagenomi

Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.

What makes Metagenomi a unique place to work?

• We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease.
• We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more! 
• We offer competitive compensation including a market-benchmarked salary, annual target bonus, equity in an early-stage startup, and a comprehensive benefits plan, including 401(k) matching, a