Discovery Postdoctoral Fellow, On-Cell NMR and HDX-MS for Drug Discovery

Band

Level 3

 

Job Description Summary

Design, implement and advance scientific experiments to support drug discovery efforts against cellular surface receptor targets.

Set-up an experimental pipeline to study protein-ligand interaction on living cells, using NMR and HDX-MS as main tools, on clinically relevant model systems. NMR and HDX-MS will be used to characterize the interaction from the ligand and protein sides respectively.

Validate the approach with orthogonal methods and in-vitro data from purified protein target.

Shape your postdoc project by exploring and committing to various key scientific questions to advance the field.

Work independently as well as with interdisciplinary teams. interact with field experts at the interface of biophysics, biology and chemistry.

Build your competency and skills as a drug hunter in the pharmaceutical industry.

Disseminate research through high-impact presentations, internal reports, and peer-reviewed publications.

 

Job Description

Internal Job Title: Discovery Postdoctoral Fellow

Position Location: onsite, Emeryville, California

#LI-Onsite

About the role

We are thrilled to open applications for our Discovery Fellowship track of the Novartis Postdoctoral Fellowship Program.

Come join Novartis Biomedical Research as a Discovery Postdoctoral Fellow and help develop on-cell NMR and MS methods for drug discovery. This research aims to uncover new therapeutic agents targeting cellular receptors, with a focus on radioligand therapies (RLT), therapeutic siRNA, and antibody-drug conjugates (ADCs) modalities.

You will be part of our Structural BioAnalytics team in Emeryville, CA, and will collaborate with researchers across the organization in Global Discovery Chemistry, Discovery Science and relevant disease areas departments. Your co-mentors, BioNMR and HDX-MS specialists, will help you develop a research program to establish this workflow together with biologists and disease area specialists.   

As part of the Discovery Fellowship track of the Novartis Postdoctoral Fellowship Program, you will join our vibrant, dedicated postdoctoral community for events, including the monthly postdoc seminars and other scheduled events for postdocs. Fellows are surrounded by a supportive, collaborative community of postdocs and scientists, who would contribute to the acceleration of your scientific growth, along with building your professional skillset, e.g. you will have the opportunity to do a Postdoc Practicum in another laboratory or in a business function of Novartis. This applied research program is up to 3 years in length, with the option of applying for an extension of up to 1 year (pending review by the Head of Biomedical Education & Innovation and the postdoc supervisor).

Discovery Postdoctoral Fellows have a unique opportunity to conduct innovative, interdisciplinary research and are expected to publish their results in leading journals. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

Through the Novartis Postdoctoral Fellowship Program, you will build your competency as a drug hunter, and as a scientific leader in the field. You will join a professional network that will support your growth as a research scientist, and you will have the opportunity to tackle disease and make an impact, by reimagining medicine together.

Estimated start date: September 2025

Key responsibilities:

As a Discovery Postdoctoral Fellow, you will:

• Design, implement and advance scientific experiments to support drug discovery efforts against cellular surface receptor targets

• Set-up an experimental pipeline to study protein-ligand interaction on living cells, using NMR and HDX-MS as main tools, on clinically relevant model systems. NMR and HDX-MS will be used to characterize the interaction from the ligand and protein sides respectively

• Validate the approach with orthogonal methods and in-vitro data from purified protein target

• Shape your postdoc project by exploring and committing to various key scientific questions to advance the field

• Work independently as well as with interdisciplinary teams. interact with field experts at the interface of biophysics, biology and chemistry

• Build your competency and skills as a drug hunter in the pharmaceutical industry

• Disseminate research through high-impact presentations, internal reports, and peer-reviewed publications<