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Staff/ Senior/ Principal Systems Engineer - R&D

Culture Biosciences
South San Francisco, USAfull_timePosted 17 Jun 2026

About the role

<div class="bb-jobs-posting__content"> <div class="bb-rich-text-editor__content ptor-job-view-description public-job-description"> <p><strong>About Us:</strong></p> <p>Culture’s mission is to simplify and accelerate bioprocess development to enable our customers to bring their biopharmaceutical products to market faster.</p> <p>With a focus on upstream cell culture process development, Culture has developed a unique platform that merges products, services and data management that can be applied to mammalian, microbial and viral vector production processes. This platform enables high-throughput process development projects to be rapidly and seamlessly executed directly by our customers in their own facilities, in our service laboratories, or both, all driven by our cloud-connected web application, accessible from anywhere, for designing, managing and analyzing experiments.</p> <p>At Culture, we combine our passions for biomanufacturing, engineering, and operations to build new solutions that make bioprocess development faster. We value curiosity, communication, collaboration, a customer focused mindset and a drive for results.</p> <h3><strong>The Opportunity:&nbsp;</strong></h3> <p>Culture Biosciences is looking for a Staff/ Senior Staff/ Principal Systems Engineer in R&amp;D as the technical authority for end-to-end system design and integration of complex, cross-disciplinary platforms. The candidate will translate Business Needs into R&amp;D objectives and system architectures.&nbsp; They define interfaces and requirements, and lead integration and verification strategy from prototype through pre-production readiness. This role resolves the hardest technical tradeoffs, drives technical alignment across teams, and raises the organization’s systems engineering bar through mentorship and standards.&nbsp; The candidate must have a strong and experienced background in Bioprocessing, Bioreactor design, and applications and have a breadth of understanding of Engineering (Mechanical, Electrical, Embedded, and Software).</p> <p><strong>What You’ll Do:</strong></p> <ul> <li>Requirements &amp; interface leadership: Establish User Needs, System Requirements, and traceability to verification and validation (clear, testable, version-controlled).</li> <li>System architecture ownership: Define the end-to-end architecture, subsystem boundaries, and interfaces across mechanical, electrical, firmware/software, controls, and test.</li> <li>Integration strategy: Build the integration plan (bring-up sequencing, dependency mapping, integration test strategy) and lead cross-functional execution through integration milestones.</li> <li>Technical tradeoff studies: Lead tradeoffs of performance, reliability, safety, cost, manufacturability, and documen

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Company

Culture Biosciences

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