Head, Oncology Clinical Development - ADCs

The Head, Oncology Clinical Development- ADCs, will report to the SVP, Head of Oncology Clinical Development. The role holder will be accountable for the design and implementation of the clinical development strategy across a particular asset across multiple tumor types spanning early- and late-phase development. This includes the strategic clinical positioning of the asset, combinations, and associated clinical development plans.

This role requires an experienced, cross-matrix senior leader capable of implementing and executing an integrated clinical strategy in support of the successful clinical development, translational research, regulatory filing and initial market launch of a growing portfolio of innovative and transformational Oncology agents.

Key Responsibilities & Accountabilities:

Clinical Development Strategy & Portfolio Leadership

• Accountable for end‑to‑end clinical development of an MOA-focused, multi-tumor asset, including registrational trials, regulatory approval, and initial market launch, ensuring scientific rigor, speed, and quality of execution.
• Shape and drive the scientific and clinical development strategy for the asset and disease areas, aligned with Oncology Tumor Team strategy and broader Oncology portfolio priorities.
• Evaluate, champion, and enable the use of novel approaches (e.g., AI/ML, innovative trial designs, external and real‑world data sources) where they add clear scientific, operational, or decision‑making value to clinical development.

Program Oversight, Governance & Visibility

• Provide oversight and connectedness across the asset program, maintaining visibility to progress, risks, dependencies, and trade‑offs across the Oncology portfolio.
• Serve as the default senior clinical representative at key governance forums (e.g., DRB, PIB, program and portfolio governance) for the asset, ensuring strong clinical leadership, continuity, and high‑quality decision‑making.
• Represent the Oncology Clinical Development organization internally and externally, including presenting at high‑impact forums such as congress all‑hands, senior leadership reviews, and advisory boards.
• Lead scientific advisory boards and other external engagements to inform asset strategy, competitive positioning, and portfolio decisions, incorporating emerging science and external expert insight.

Cross‑Functional Leadership & Connector Role

• Act as a senior connector across functions, partnering closely with Oncology Research, Precision Medicine/Companion Diagnostics, Medical Affairs, Commercial, Competitive Intelligence, and Global Product Strategy to drive integrated development and lifecycle planning.
• Drive asset alignment across research, development, and commercialization planning, and ensuring cohesive execution against shared objectives.
• Build and sustain strong internal and external partnerships to accelerate decision‑making, resolve complexity, and optimize development outcomes in a matrixed environment.

Culture & Capability Building

• Foster a culture of empowerment, scientific excellence, inclusion, and collaboration, aligned with OneOncology values, while modeling strong, visible leadership.
• Actively remove organizational barriers and enable teams to operate effectively and autonomously within a complex, global matrix environment.

Standards, Processes & Continuous Improvement

• Contribute to the establishment and continuous evolution of clinical development standards, processes, and best practices across Oncology, ensuring consistency, quality, and regulatory readiness.
• Ensure timely access to relevant external scientific and competitive intelligence (e.g., congress data, emerging science, competitor activity) to inform clinical development decisions and portfolio strategy.

Skills & Capabilities

• Senior clinical and scientific leadership in early‑ and late‑phase oncology drug development, including FTIH through registrational trials and launch readiness.
• Strong ability to translate science and translational insight into differentiated clinical development strategies across disease areas and portfolios.
• Proven capability to operate at portfolio level, balancing priorities, risk, and resources while maintaining asset‑level rigor and accountability.
• Credibility and effectiveness representing Clinical Development at senior governance forums, with strong executive presence and influence.
• Advanced cross‑functional and matrix leadership skills, with a natural connector mindset across research, development, medical, commercial, and precision medicine partners.
• Openness to and fluency with innovative development approaches (e.g., AI/ML, novel trial designs, extern