Senior Principal Operational Scientist – Aging & Metabolism

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world.  We provide an inclusive work environment where each person is considered as an individual.  At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Cambridge, Massachusetts, United States of America, Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
 

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Principal Operational Scientist – Aging & Metabolism to be in Cambridge, MA or Spring House, PA.

Purpose:
The Senior Principal Operational Scientist will provide scientific leadership and hands‑on support for translational research in thrombosis, sarcopenia, and cardiometabolic diseases, while also delivering key operational support. This hybrid role combines scientific responsibilities (in vivo and in vitro work) with operational functions, including project management, coordination of contracting, and administrative and laboratory support. The position requires integrating cardiopulmonary disease mechanisms, aging biology, and metabolic dysfunction while ensuring smooth execution across a cross‑functional research portfolio.

You will be responsible for:
 

Scientific and Strategic (~50%)

• Lead and provide expertise in in vitro and in vivo studies supporting cardiometabolic and cardiopulmonary research.
• Contribute to target identification, validation, and preclinical strategy development in areas such as HFpEF, Group 2 PH, vascular dysfunction, thrombosis, and age‑related muscle loss and weakness.
• Partner with disease area leaders and project teams to develop mechanistic hypotheses and experimental plans aligned with Cardiopulmonary priorities.
• Uphold strong scientific standards through rigorous data interpretation, clear internal communication, and contributions to publications and presentations.
   

Project Management, Coordination, and Administrative (~50%)

• Support project management for aging‑focused cardiopulmonary programs, ensuring clear milestones, timelines, and decision points.
• Prepare and maintain project documentation, including development plans, data packages, governance materials, and decision‑support documents.
• Organize and support internal and external meetings by preparing agendas, documenting outcomes, and ensuring timely follow‑up on action items.
   

Qualifications / Requirements:

Education:

• Bachelor’s degree is required
• Master’s degree or PhD is highly preferred
   

Required:

• Minimum of 8-10 years’ experience working in muscle biology, cardiovascular, and metabolism in the Pharmaceutical/Biotechnology industry (which can include education)
• Strong scientific background in biology (e.g., aging, metabolism, cardiopulmonary, muscle biology) or in chemistry/biologics.
• Experience contributing scientifically to drug discovery or translational programs in cardiometabolic, cardiovascular, or muscle‑related disease.
• Demonstrated experience working in cross‑function