Director of Annual and Major Giving (Reproductive Healthcare - Remote)

Organizational Summary

Contraceptive care is basic health care. Yet too many patients in the U.S. struggle to access the care they want, when they want it. 

A national nonprofit founded in 2014, Upstream USA partners with healthcare organizations to provide free training, education, and technical assistance to improve their contraceptive services and meet their patients’ needs – at no cost to them. Over ten years, we’ve supported 200+ healthcare partners (including primary care practices, federally qualified health centers, health systems, and more) with a transformative approach that empowers patients to access the contraceptive care where they already receive most of their healthcare. We’re on a path to partnering with health care organizations that collectively serve 5 million patients by 2030.

We do not accept funding from pharmaceutical companies or the government. Our work is made possible by generous support from venture philanthropy. That privilege comes with high expectations about growth and scale and a focus on measurable outcomes and impact. 

We’re a 2023 Audacious Project recipient that continues to garner attention from many leading publications, including Harvard Public Health, Bloomberg, MedPage Today, Baltimore Sun, the Fresno Bee, and WBUR. We welcome individuals interested in career opportunities, partnerships, or philanthropic endeavors seeking additional information to visit our website (www.upstream.org) or email us at info@upstream.org.

Position Summary

The Director of Annual and Major Giving is a key, revenue-focused leadership role responsible for driving and executing Upstream's comprehensive strategy for individual and institutional donors who give up to $1 million.

This Director will lead the organization's efforts to achieve ambitious annual and multi-year revenue goals by simultaneously overseeing the annual giving program and managing a high-potential portfolio dedicated to cultivating and stewarding six-figure philanthropic commitments.

Reporting to senior leadership, this position requires a proactive self-starter with a demonstrated history of securing major gifts, exceptional project management skills, and the ability to operate with urgency and precision. The Director will serve as a strategic partner to senior leadership, leveraging internal collaboration and external market awareness to translate Upstream's mission into compelling, personalized engagement strategies that strengthen donor relationships and maximize financial support.

Essential Duties and Responsibilities

Strategy and Revenue Leadership

• Lead and implement Upstream’s annual and multi-year strategies to achieve major donor and annual giving revenue goals for individual and institutional donors giving up to $1 million.
• Monitor performance against revenue targets and adjust strategy based on results and emerging opportunities.
• Co-develop annual goals, KPIs, and reporting frameworks in partnership with leadership.
• Produce regular reports tracking progress toward goals, KPIs, and donor engagement metrics.
• Secure between $1-1.5million in unrestricted revenue from major and annual donors in 2026.

Major Donor Portfolio Management

• Manage and prioritize a portfolio of up to 75 of  Upstream’s highest potential major gift prospects and donors.
• Develop and implement tailored strategies for managing a portfolio of major donors, ensuring proactive, personalized engagement through in-person, phone, and virtual touchpoints.
• Strategically and opportunistically cultivate new major donors to expand and strengthen the portfolio.
• Lead preparation for donor meetings, including scheduling, researching profiles, as well as drafting briefing materials, talking points, slides, deliverables and follow-up correspondence.

• Design, write, and project manage tailored donor engagement and communication strategies that leverage investor relations and marketing assets, ensuring the de