Senior Scientist

In vivo Senior Scientist, Oncology Small Molecules  

Waltham, MA 

This Opportunity: 

We are seeking a highly motivated Senior Scientist with a track record of scientific excellence in in-vivo pharmacology to join our Oncology Small Molecules team in Waltham MA USA. As a Senior Scientist, you will be leading from the bench delivering in vivo pharmacology data to support our oncology small molecules portfolio, with a focus on drugs targeting Breast, Ovarian, Lung and Colorectal cancers. 

Key Responsibilities: 

• Use in vivo technical skills to support our oncology platform by: 

• Working hands-on in the lab developing and working with various in vivo models of cancer including subcutaneous and orthotopic xenograft models and Patient Derived Xenograft models. 

• Designing and executing in vivo pharmacology studies (tolerability, PKPD, and efficacy) and delivering comprehensive in vivo pharmacology data packages to support early and late-stage drug discovery programs. 

• Profiling of tissue samples to explore mechanisms of drug response and resistance using both traditional and novel approaches. 

• Work collaboratively across disciplines to develop and implement aggressive work plans and timelines. 

• Demonstrate proficiency and flexibility in working with various programs and databases to capture all study data for broad access by project teams and stakeholders. 

Essential requirements:  

• BS/MS with 5+ years’ experience or PHD with 2+ years of experience in biology, pharmacology, or related field with a minimum of 2 years “hands-on” in vivo experience.  

• Practical in vivo experience and experimental skills in the use of mouse models. 

• Ability to work both independently as well as within project teams and across disciplines such as DMPK and translational medicine. 

• Exceptional communication, listening and organizational skills. Ability to analysis, organize and present data in an appropriate manner for a given audience.   

• Understanding of statistical methods and quality control of data. <