Senior Research Associate, In Vivo Biology

Company Summary:

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability.

Prologue Medicines is dedicated to transforming drug discovery by leveraging deep biological insights and cutting-edge scientific innovations. Our mission is to deliver breakthrough therapies that address critical unmet medical needs. As part of our dynamic and collaborative team, you will have the opportunity to impact human health on a global scale.

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

 

Position Summary:

Prologue Medicines are seeking a highly motivated and detail-oriented Senior Research Associate to join our dynamic In Vivo Biology team, leading projects in discovery and pre-clinical development for therapeutic proteins of viral origin. The successful candidate will play a key role in designing, executing, and analyzing in vivo studies to evaluate therapeutic proteins with the aim of nominating development candidates, and supporting preclinical development and translational science of these molecules through to IND and beyond.

As a member of our team, you will be responsible for designing and executing experiments to understand the activity, mechanism of action, and therapeutic potential of early-stage biologics in vivo. This role offers the opportunity to work in a dynamic, fast-paced, entrepreneurial environment, working independently as well as collaboratively within a highly integrated team. This is an on-site role in Cambridge, MA.

Key Responsibilities:

• Planning, execution, and analysis of in vivo experiments to evaluate the therapeutic potential of our test articles including pharmacokinetic/pharmacodynamic, biodistribution, and efficacy studies.
• Conducting ex vivo wet lab experiments to analyze PD phenotypes and MoA in different tissues.
• Ability to work independently and as part of a collaborative team to design, plan and execute experiments, and manage outcomes to support research activities, project goals, and platform development.
• Creative and strategic contributions to the discussions, designs, and implementation of in vivo and ex vivo
• Managing relationships with external research facilities.
• Reporting results to the scientific team and management.
• Critical data analysis, attention to detail, and troubleshooting abilities.
• Maintaining an organized and up-to-date electronic lab notebook.
• Writing, updating, and maintain high-quality experimental protocols.

 

Basic Requirements:

• Bachelor’s or MS degree with 5+/3+ years of relevant experience with in vivo and ex vivo lab experiments in academia or industry.
• Extensive experience with mouse handling: injections (IV, IM, IP), blood collection, and tissue harvesting is essential.
• Performing and recording animal health observations, communicating adverse findings to the veterinarian technicians to ensure animal care standards are in keeping with applicable laws and regulatory guidelines.
• Writes and maintains animal protocols.
• Experienced with various ELN and LIMS systems.
• Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner, document results in laboratory notebooks.
• Demonstrated ability to work in a highly collaborative team environment.
• Motivated and excited about biological discovery and assay development.
• A dynamic problem solver and self-starter

Preferred Requirements:

• Hands on experience in a variety of ex vivo analysis techniques