Director, RWE Scientist

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

The Director, Real-World Evidence (RWE) Scientist designs, executes, and delivers real-world studies within the HEOR/RWE function, with a primary focus on the atumelnant program — congenital adrenal hyperplasia (CAH), adult and pediatric, and Cushing's disease — through launch and into lifecycle management. Reporting to the Senior Director, Head of the RWE Center of Excellence, the Director owns Crinetics' CAH real-world data assets and leads the execution of the full range of observational studies — burden of illness, natural history, patient journey, treatment patterns, drug utilization, external control arms, and comparative effectiveness — using large healthcare databases (claims, EHRs, registries, linked datasets) and primary RWD collection. Working from evidence priorities defined by the HEOR/RWE Therapeutic Area (TA) Leads and direction from the RWE COE Head, the Director ensures continuity of atumelnant RWE through launch and produces rigorous, timely, decision-ready real-world evidence. The Director leads external analysts and study vendors, providing strategic oversight, mentoring, and quality assurance while maintaining the ability to engage deeply with analytics and study design.

Essential Job Functions and Responsibilities:

These may include but are not limited to:

• Design and execute real-world studies for the atumelnant program (CAH adult, CAH pediatric, Cushing's disease), including burden of illness, natural history, patient journey, treatment patterns, drug utilization, external control arms, and comparative effectiveness.
• Own and steward Crinetics' CAH real-world data assets—ensuring continuity, documentation, and reusability of cohorts, code lists, and analytic datasets.
• Lead analyses using large healthcare databases (insurance claims, EHRs, registries, linked datasets) and primary RWD collection (chart reviews, surveys).
• Develop study protocols, statistical analysis plans, and feasibility assessments; perform database selection and confirm that patient counts and study variables exist in available data.
• Ensure continuity of atumelnant RWE through launch, maintaining institutional knowledge of CAH RWE assets and program evidence needs.
• Translate evidence priorities set by HEOR/RWE TA Leads, under direction from the RWE COE Head, into executable analyses tied to launch and lifecycle milestones.
• Apply rigorous epidemiologic and outcomes-research methods, including appropriate causal-inference and bias-control techniques for observational data.
• Lead and mentor external analysts supporting in-house RWE analytics projects—scoping the work, directing analyses, and reviewing deliverables for methodological quality.
• Oversee RWE study vendors when analyses are outsourced—managing CRO/data-vendor execution against scope, timelines, budget, and deliverable quality.
• Contribute RWE outputs to integrated evidence plans, value dossiers, and HTA submissions in partnership with TA Leads and cross-functional stakeholders.
• Collaborate with the RWE Center of Excellence, Modeling & Simulation, Biometrics, and external data and analytics partners on study design and execution.
• Prepare manuscripts, abstracts, and congress presentations communicating RWE findings.
• Ensure compliance with corporate policies and US healthcare laws and regulations governing real-world data use.
• Other duties as assigned.

Education and Experience:

Required:

• Advanced degree in epidemiology, biostatistics, health services research, health economics, or related discipline (PhD, MD, PharmD, MPH, MSc).
• Minimum of 10 years of relevant pharmaceutical, biotech, or HEOR consulting experience executing observational research.
• Proven experience leading and developing teams, including external analysts or vendor partners.
• Equivalent combination of education and applicable job experience may be considered.
• Demo