Senior Associate Scientist, Pharmacology

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Background

RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, RayzeBio focuses on improving survival for people with cancer by harnessing the power of targeted radioisotopes. The company operates as a standalone entity within BMS, maintaining its biotech culture while leveraging best-in-class oncology capabilities. RayzeBio is developing innovative drugs targeting solid tumors, with its lead asset, RYZ101, in Phase 3 testing for gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and earlier-stage testing for small cell lung cancer (SCLC). The company is led by a successful, experienced entrepreneurial team and aims to be the global leader in radiopharmaceuticals.

Job Description

This laboratory-based role offers an exciting opportunity to advance novel radiopharmaceutical therapies from bench to bedside. The Senior Associate Scientist will participate in discovery and translational research by conducting in vivo experiments and managing vivarium duties, including experiment design, execution, tissue collection, and data analysis. The role also includes in vitro mechanistic studies and cross-functional collaboration with teams in translational research, medicinal chemistry, and other scientific disciplines. The successful candidate will receive mentorship from senior scientists and must adhere strictly to radiation safety protocols.

Key Responsibilities

• Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, therapeutic efficacy, and durability of response across various treatment modalities, including radiopharmaceutical agents.
• Perform essential in vivo procedures: cell culture, tumor cell and PDX fragment implantation, sampling, dosing (IV, SC, IP, PO), tumor and body weight monitoring, and necropsy.
• Analyze and interpret experimental data independently; present findings at project team meetings, departmental reviews, and company-wide forums.
• Conduct in vitro experiments (e.g., cell viability, cytotoxicity, proliferation, apoptosis, DNA damage response, pathway interrogation) using molecular biology techniques.
• Work with radioactive materials in strict compliance with institutional and federal radiation safety protocols.
• Support laboratory operations, including inventory management, equipment maintenance, and ensure strict compliance with company policies, GLP, IACUC, and animal welfare guidelines, including accurate documentation in laboratory notebooks and electronic records.
• Collaborate effectively within the immediate team and cross-functionally to advance program objectives.
• Demonstrate initiative and technical expertise in troubleshooting experimental issues and ensuring accurate data analysis.
• May involve working outside standard business hours, including weekends, holidays, and early mornings, to support critical in vivo studies and project deadlines.

Education and Experience

• B.Sc. with 4–5+ years of experience or M.Sc. with 2–3+ years of experience in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline.
• Prior hands-on experience in pre-clinical drug discovery programs (industrial or academic settings) is preferred.
• Prior experience working with radioactive materials is strongly preferred.

Skills

• Technical proficiency in rodent handling (immune-compromised and -competent mice), aseptic procedures, and lab animal research.
• Ability to perform IV compound administration and SC engraftment is mandatory.