Director, Chemistry

Job Description

Director, Discovery Process Chemistry, Rahway

Description

The Director, Discovery Process Chemistry is responsible for managing a portfolio of projects from the preclinical pipeline of new company products. The incumbent will also have to direct a team of discovery process chemists responsible for facilitating medicinal chemistry research by overcoming synthetic bottlenecks to chemical intermediates and active pharmaceutical ingredients (API), streamlining structure-activity relationship studies. The position is also accountable for successful transition of compounds from discovery research into development by closely interacting with discovery and preclinical research colleagues to maximize speed of transition to the clinic in accordance with preclinical workflows including management of API supply during this period. 

Nature and Scope of Position

The Director reports to the Executive Director of Discovery Process Chemistry, Process Research & Development in the company's Research Laboratories organization. This role has direct supervisory responsibility of approximately 10 scientists who work closely within multidisciplinary teams comprised of discovery and development scientists. The incumbent will be responsible for the recruiting, appraisal, and development of personnel under their supervision. The Director selects, trains, and effectively recommends transfers, merit increases, promotions, and closures of personnel under their direction within the framework of Company policy.

Critical tasks involve oversight of new route design and synthetic methodology development, scale-up, support of API campaigns for discovery and preclinical efforts; transferring appropriate technical information to support the preparation of API across internal sites and in collaboration with external partners. Proactive resourcing planning, risk assessment strategies and budget management will be necessary. The Director will also be a member of the core-team for the discovery review committee responsible for oversight of the discovery portfolio in a therapeutic area, including influence in approval of potential candidates for preclinical development.

The Director establishes, recommends, and maintains external contacts for Process Research & Development, particularly locally in New Jersey. Interaction with the local academic community is expected.

Qualifications

Education:

• Ph.D. in chemistry, or related pharmaceutical science is required.

Required:

• Five or more years of drug discovery or drug development experience and demonstrated ability in leading cross-functional groups.
• Track record and commitment to employee development/retention.
• Excellent interpersonal, communication, and collaboration skills.
• An understanding of the interplay between medicinal chemistry SAR processes, physical properties and safety assessment for preclinical study designs will be critical.
• Subject matter expertise in process chemistry, especially with regards to early development is expected.
• Strength in delivering results on firm deadlines.
• Demonstrated ability in selection and prioritization of a portfolio of projects.
• Internationally recognized in the pharmaceutical development area.

Location:

• Rahway, NJ location is required.

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