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Staff Full Stack Applications Engineer (AI Apps Focus)

GeneDx
UKRemotefull_timeVerifiedPosted 29 Oct 2025

About the role

Summary 

As a public and profitable company, we have ambitious plans to scale and enhance our AI-powered products and services. We're looking for software engineers who can work holistically to design strategic AI application solutions that go beyond just writing code. A strong track record in understanding business needs, communicating effectively, and delivering impactful AI-driven results is essential, along with leadership qualities to guide and inspire colleagues. 

As a Staff Full Stack Engineer, you'll play a key role in advancing our AI technology platform and building intelligent software products that make a meaningful impact. You'll have the opportunity to lead large-scale technical efforts across multiple platforms that address our long-term AI strategy. You'll be expected to propose novel solutions to real-world business challenges using AI, work cross-functionally with engineering and non-engineering peers, and drive innovative solutions that enhance our user experiences through intelligent interfaces and workflows. The ideal candidate will also have a track record of being an effective thought leader and improving engineering best practices across the organization. 

Job Responsibilities 

  • Design, develop, and maintain high-quality, full-stack AI-enabled software solutions that are scalable, reliable, and easy to maintain. 
  • Build data-intensive chat interfaces that effectively harness AI capabilities and provide exceptional user experiences.
  • Develop provenance-aware form fills and intelligent summarization features that enhance productivity and accuracy. 
  • Create flexible, reusable frameworks for building AI-enabled applications that can be leveraged across the organization.
  • Lead architecture and system design efforts for complex, distributed AI applications, ensuring alignment with long-term business and technical goals.
  • Collaborate with cross-functional partners in product, design, and business teams to translate strategic AI initiatives into technical solutions.
  • Mentor and coach engineers, fostering a culture of technical excellence, continuous learning, and knowledge sharing around AI application development.
  • Champion engineering best practices and drive initiatives that improve system performance, code quality, and developer productivity across the organization.
  • Be tech lead of a small squad of full stack engineers, providing technical direction, mentorship, and hands-on support. 

Education, Experience, and Skills 

  • 8+ years experience in full stack software development with a strong focus on modern web applications.
  • Expert-level proficiency in TypeScript with extensive experience building production-grade front-end applications.
  • Strong proficiency in Python for backend development, particularly in AI/ML integration contexts.
  • 7+ years experience building large-scale front-end applications using React (highly preferred) or other modern frameworks (Vue, Angular).
  • 7+ years experience developing back-end services and APIs in a distributed, service-oriented architecture using multiple paradigms (e.g. REST, RPC, GraphQL).
  • Demonstrated experience building AI-powered user interfaces, including conversational interfaces and intelligent data processing workflows.
  • Strong experience with data modeling using multiple database and storage types, particularly for AI application contexts.
  • 5+ years experience designing and deploying resilient and scalable distributed services in the cloud using Docker and Kubernetes (e.g. AWS, GCP, Azure).
  • Applied knowledge of multiple architectural paradigms and design patterns for AI applications. 

Bonus Points For 

  • Experience with AI SDK, assistant-ui, or similar AI application typescript frameworks.
  • Experience building document viewing and manipulation interfaces, particularly with PDFs.
  • Prior healthcare / health tech experience, or experience in other regulated industries, particularly with data privacy and compliance requirements.
  • Experience with LLM integration, prompt engineering, and RAG (Retrieval-Augmented Generation) architectures.
  • Contributions to open-source AI application projects or frameworks. 

 

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Science - Minded, Patient - Focused. 

At GeneDx, we create, follow, and are informed by cutting-edge science. With over 20

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GeneDx

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