Senior Program Manager

Location Type: Remote (USA) with up to 25% travel

ABOUT FORESIGHT DIAGNOSTICS

Foresight Diagnostics is a molecular diagnostics company pioneering non-invasive cancer detection through highly sensitive, cell-free DNA-based liquid biopsy technologies. Our proprietary methods - originally developed at Stanford University - are designed to detect smaller tumors earlier and enable more personalized treatment strategies for patients with cancer.

We sit at the intersection of molecular biology, bioinformatics, and next-generation sequencing (NGS), and we translate rigorous science into clinically meaningful solutions. Following our acquisition by Natera, we now combine the agility of a mission-driven startup with the scale and resources of a global leader in cell-free DNA testing. It’s an exciting moment to join us.

Headquartered in Boulder, Colorado, our team operates in a high accountability, collaborative environment where quality and continuous improvement aren’t just values - they’re how we work every day.

WHY THIS ROLE EXISTS

The Senior Program Manager will lead complex, cross-functional initiatives supporting operational programs at both the Austin, TX and Boulder, CO sites. Projects and Programs may include operational and site readiness for product and clinical trial launches; initiatives to improve, scale, or automate wet lab and dry lab workflows; and product sustainment and lifecycle management efforts, such as change management for reagent obsolescence, supplier transitions, and integration of vendor-driven software or platform upgrades.

This role owns end-to-end program strategy and execution, aligning stakeholders across laboratory operations, clinical development, R&D, manufacturing, regulatory, quality, software, and external partners. The Senior Program Manager will own, drive, communicate, and engage all project partners to enable accountability, problem solving, and on-time/within-budget delivery for simultaneous projects and programs. Success in this role requires onsite engagement (up to 25% travel) to facilitate rapid decision-making, build alignment, and resolve issues in a highly collaborative, fast-paced setting. This position reports to the Associate Director of Program Management.

WHAT YOU’LL DO

• Own end-to-end delivery of complex operational programs, including scope, schedule, budget, and resource strategy, ensuring alignment with regulatory and business requirements

• Lead cross-functional program execution across laboratory operations, clinical operations, R&D, and external partners to deliver on translational research, clinical, and commercial timelines

• Drive operational readiness initiatives, including laboratory site readiness for product and clinical trial launches, and process implementation across wet lab and dry lab workflows

• Adhere to and facilitate the formal governance processes to communicate program status, risks, dependencies, and trade-offs; escalate issues as needed; and present data-driven recommendations and business proposals to senior leadership to enable timely, informed decision-making

• Develop and maintain program roadmaps, ensuring alignment with organizational priorities and securing stakeholder buy-in

• Extract and refine user needs and requirements from stakeholders and lead teams to focus on the most valuable deliverables.

• Lead risk and issue management, proactively identifying, mitigating, and resolving complex technical and operational challenges

• Ensure adherence to regulated processes, including design controls, change management, and quality system requirements (FDA, CAP/CLIA)

• Drive cross-functional accountability, influencing without direct authority to ensure alignment, ownership, and timely execution

• Partner with Alliance Management and external stakeholders to ensure seamless execution of joint programs and delivery commitments

• Champion continuous improvement throughout the organization, identifying and acting on opportunities to enhance operational efficiency

• Cultivate, build and maintain positive and collaborative relationships with cross-functional teams

WHAT YOU’LL BRING

• 5-7+ years of experience in program management, or equivalent combination of project and program management and relevant functional experience in biotechnology, diagnostics, clinical laboratory, or life sciences

• Experience supporting laboratory operations, clinical operations and trial execution (preferred)

• Background in NGS diagnostics, includi