Senior Principal Scientist, Protein Engineering

Job Description

Our company's Discovery Biologics is seeking an exceptional Senior Principal Scientist protein engineer, based in South San Francisco, to utilize advanced engineering methods to design biomolecules in our pipeline from lead identification through PCC declaration.  The position requires deep expertise in protein engineering and vast experience in the discovery and development of protein therapeutics, both in silico and wet lab.  This is primarily an individual contributor role with supervisory responsibilities over a small team.  The position reports to the Head of the Protein Engineering Center of Excellence.

We recognize that the diversity in our team is our strength and are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of scientists to drive our core mission.

Key Responsibilities:

• Apply advanced protein engineering methods, including sequence-, structure-, and AI/ML- based, to drive the invention of novel biologic therapeutics

• Serve as a project co-lead on pipeline projects to advance biologics candidates through PCC

• Serve as a scientific mentor and resource for scientific staff across the company's Discovery Biologics network

• Lead direct reports to drive their pipeline impact and personal growth and development

• Foster a high-performance culture of collaboration, engagement, self-accountability and inclusion

• Effectively partner across multidisciplinary interfaces to achieve organizational objectives

• Support partnerships and partnering opportunities with biotech and academia to drive new and existing capability collaborations and evaluations

• Stay abreast of external advancements in the relevant scientific fields

• Promote the external reputation of our company's Discovery Biologics through presentations and publications

Qualifications:

Education:

• Ph.D. (with a minimum of 10 years), Bachelor's or Master's (with a minimum of 15 years) in life sciences and relevant industry experience

Required Experience and Skills:

• Expert-level competency in advanced protein engineering methods in the design of biotherapeutics

• Deep scientific knowledge across workflows and domains integral to the discovery of protein therapeutics, including antibody discovery, protein expression/purification, protein characterization and developability assessment

• Demonstrated track record of utilizing protein engineering methods, including structure- and AI/ML– based to advance biotherapeutics through discovery and into the clinic

• Experience mentoring and developing colleagues through formal and informal means.

• Exceptional communication and collaboration skills

• Has established of a strong external reputation through high-impact publications, presentations, and scientific community engagement

Preferred Experience and Skills:

• Experience in protein therapeutics beyond traditional mAbs including alternative non-Ig scaffolds, bi- or multispecifics, ADCs, TCEs, and fusion proteins

• Hands-on experience in wet lab execution of one or more of the following: protein expression, purification, and/or characterization (developability, biophysics, functional assessment, assay development/execution, structure determination)

• Project leadership experience across Discovery stages, from tool-molecule generation through preclinical development of therapeutic candidates

• Experience in managing external collaborations and participating in diligence activities

• Prior line management experience

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To