Scientist/Sr. Scientist, Integrated Attribute Science - Allogeneic Cell Therapy

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Title: Scientist/Sr. Scientist, Integrated Attribute Science

Location: Seattle, WA

At Bristol Myers Squibb we are reimagining the future of cell therapy. With our bold ambition, backed by a best-in-the-industry team and long-term commitment, we are leading the way to unlock the full promise of cell therapy as we strive to put more patients on the path to a cure. If you are ready to challenge yourself, accelerate your career, and give new hope to patients, there’s no better place than here at BMS with our Cell Therapy team.

The Cell Therapy Integrated Attribute Sciences (IAS) department is seeking a Scientist or Senior Scientist to support the development of the Allogeneic Cell Therapy pipeline programs. The goal of BMS Cell Therapy is to revolutionize medicine by re-directing the body’s immune cells to specifically target cancer cells. Allogeneic or “off-the-shelf” CAR T cells are generated from healthy donor-derived T cells rather than the patient’s T cells and can be delivered to patients without manufacturing wait time. The Attribute Sciences Team is responsible for developing and executing in depth vector, starting materials, drug product characterization and mechanism of action studies to support the development of gene-engineered allogeneic and autologous cell therapies.  The primary focus of the Attribute Sciences Scientist/Senior Scientist role will be to build to collaborate with IAS team member to build in depth allogeneic CAR T cell product and manufacturing process data and understanding with particular focus on exploratory/investigational studies to support:

The identification of drug product critical quality attributes (CQA) to inform the overall product control strategy for the manufacturing of high quality, best in class allogeneic cell therapy products The generation of product quality target product profiles taking into account safety and efficacy of drug products Support process development studies and investigations by building and mining in depth data packages and generating hypothesis-driven conclusions and proposed risk mitigation strategies Generate in depth product characterization data packages for inclusion in regulatory submissions (with specific attention to Module 3 S.3.1. Elucidation of Structure) and to answer agencies’ information requests

Successful candidates will have a strong foundation in Immunology and human T cell biology and experience with the design, optimization, and implementation of a broad range of in vitro cell-based and/or molecular T cell characterization assays (i.e. cytotoxicity assays, proliferation, cytokine production assays, multi-color conventional and spectral flow cytometry, gene editing, transcriptome and proteome profiling, etc.). Prior research experience with T cells / CAR T cells (including cell therapy research, allogeneic hematopoietic stem cell transplantation, etc) will be prioritized.

This role is highly collaborative and requires strong ability to prioritize deliverables, independence, a demonstrated ability to support cross-functional teams, attention to detail, a healthy sense of urgency, and a passion for exploratory and investigational science.

Key Responsibilities:

• Work collaboratively with Integrated Attribute Sciences Team members to identify, prioritize and support immediate IAS team goals and deliverables requiring the application of in depth drug product and starting materials characterization technologies and platforms for execution
• Design, optimize and execute in-depth characterization experiments of cell therapy starting materials and drug products to answer high priority targeted questions (such as investigation of produ