Principal Scientist, Cancer Immunology Discovery Biology

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Oncology Thematic Research Center at BMS is a key research engine, responsible for the discovery of novel oncology therapeutics for patients with cancer.  Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies.  With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome.  We are a fully integrated drug discovery and translational organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology and Immuno-oncology to identify and validate targets.   We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.  We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.”

Position Summary:

We are seeking an innovative and independent lab-based scientist with extensive experience independently designing and conducting experiments to further the discovery and characterization of novel, multi-specific antibody immune-oncology assets.  The successful candidate will join the Cancer Immunology Discovery Biology Team within the Oncology Thematic Research Center at Bristol Myers Squibb in Cambridge, MA.

This individual will be dedicated to designing and executing experimental studies related to the decisional progress of our cancer immunology programs throughout the portfolio from early stages, including target validation and prioritization, to lead discovery and characterization, and ultimately IND filling. The candidate will also lead design and development cellular assays to explore target biology, enable compound triaging, assess target engagement, and probe mode of action characterization of antibody therapeutics.  The individual will work collaboratively with other functions, such as informatics and predictive science, lead discovery and optimization, in vivo pharmacology, and translational research teams to design/execute work related to patient stratification, identification of appropriate PD markers and assay development/transfer for miniaturization, among others.

Position Responsibilities:

In the role as a Principal Scientist within Cancer Immunology Discovery Biology, the ideal candidate will:

• Apply extensive technical knowledge to leverage current and new techniques to design and implement studies critical to drive hypothesis-driven research with complex antibody therapeutics.

• Independently design, troubleshoot, execute, and interpret cutting edge in vitro and ex vivo experiments with multi-specific antibody therapeutics

• Development assays to explore target biology, enable large molecule triaging, and probe mode of action of complex biologics including multi-specific antibodies. 

• Perform laboratory work related but not limited to tissue culture, multi-parametric flow cytometry, western blot, immune cell culture using activation/expansion/exhaustion assays, proliferation and tumor killing assays, 2D/3D co-culture activity assays, ELISA, Luminex, processing of DNA/RNA/protein.

• Maintain accurate and detailed record-keeping.

• Collaborate across highly matr