Sr. Scientist, Protein and Antibody Bioconjugation

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

About the Role:

We seek a Bioconjugation Sr. Scientist to join our Bioconjugates Research Group. The successful candidate will contribute to the design, generation, and characterization of novel bioconjugate modalities, including antibody-peptide conjugates (APC), antibody-oligonucleotides conjugates (AOC), and antibody-drug conjugates (ADC). Your expertise in protein and antibody conjugation will enable you to have a significant impact on Neurocrine’s pipeline of innovative therapeutics.

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Your Contributions (include, but are not limited to):

• Carry out laboratory functions, plan and design experiments, and apply technical knowledge and skills to achieve project goals in a precise and timely manner

• Design, synthesize, and characterize antibody conjugates using state-of-the-art bioconjugation methods, purification processes, and biophysical techniques

• Optimized conjugation protocols using novel chemistries and techniques for a variety of bioconjugates modalities such as peptide-antibody (APC), oligonucleotides-antibody (AOC) and small molecule antibody (ADC) conjugates. Experience with different conjugation strategies, such as stochastic vs site-specific conjugation, is desirable

• Identify and troubleshoot critical issues within conjugation processes, resolving them promptly to ensure consistent progress and quality

• Collaborate cross-functionally with chemists and other teams to design and establish linker-payload biologic SAR (structure-activity relationships), supporting scientific discovery and project progression

• Tracks progress against the timelines of ongoing projects, ensuring timely delivery of results and providing regular updates to project teams and stakeholders

• Effective communication of scientific rationale, results, and interpretation at project, team and departmental meetings, contributing to strategic discussions

• Establish and maintain excellent working relationships with critical collaborators throughout the company

• Maintains accurate and well-organized lab notebooks and batch