Senior Research Associate, Proteomics

Company Summary:

Tessera Therapeutics is pioneering Gene Writing™— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

Position Summary:

The Senior Research Associate will be responsible for developing, validating, and employing LC/MS based proteomics approaches to analyze biological samples to support research, non-clinical, and clinical development programs for a variety of therapeutic indications. The ideal candidate must have excellent communication skills and is willing to work in a fast-paced work environment. We are searching for a driven, enthusiastic and self-motivated individual who is comfortable multitasking and working independently on various aspects of the platform. This individual will join a dynamic, rapidly growing, and highly collaborative team

 

Key Responsibilities:

• Perform LC-MS-based proteomics experiments and optimize experimental protocols, sample preparation, and instrument parameters to ensure high-quality data generation
• Prepare biological samples (tissues, cells, biofluids) for LC-MS analysis, including protein extraction, digestion, sample clean-up and using various enrichment techniques (e.g., immunoprecipitation) to enhance detection sensitivity.
• Operate and maintain state-of-the-art LC-MS systems and associated software (Proteome Discoverer, Biopharma Finder, FragPipe, Skyline, etc).
• Generate reports and present results to cross-functional teams.
• Collaborate effectively with multidisciplinary teams of researchers, including biologists, bioinformaticians, and statisticians. 
• Assist training of lab personnel.

 

Basic Qualifications:

• Bachelor's degree in relevant scientific discipline with 5+ years industry experience; or a Master’s degree in relevant scientific discipline with 3+ years of industry experience.
• Experience in LC-MS based proteomics is required.
• Excellent knowledge and hands-on experience in proteomics sample preparation techniques such as immuno-protein/peptide enrichment and LC-MS based method development and data processing for protein characterization and quantification applications.
• Extensive experience in protein isolation and purification from complex biological samples, such as cells, tissues, and biofluids.
• Experience in using XCalibur, Skyline, Proteome Discoverer, or BioPharma software.
• Excellent organizational and communication skills.
• Ability to conduct multiple laboratory and project tasks efficiently.
• Ability to work in a team-oriented environment.

Preferred Qualifications:

• Experience in both Orbitrap LC-MS and Triple Quadrupole LC-MS is preferred.
• Experience in targeted proteomics is preferred.
• Experience in proteomics assay development/validation is preferred.   

More About Flagship Pioneering

Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

 

Recruitment & Staffing Agencies:  Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.  The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneerin