Senior, Research Investigator

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America’s Best Large Employers in 2023.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Posted Job Title

Senior, Research Investigator

Job Profile Title

Research Investigator, Senior

Job Description Summary

In this position, the candidate will design, manufacture and test new constructs for in vivo T cell and hematopoietic stem cell transduction. Experiments will range from in vitro demonstration of antigen-specific transduction of candidate cell subsets under various culture conditions, to testing their anti-tumor function, through to in vivo injection and determination of pharmacokinetics/biodistribution along with on-target specificity and anti-tumor effect. In addition, the candidate will oversee and teach new graduate student and post-doctoral scholar experimental skills including molecular cloning, viral production and titration, cell culture, T cell function studies, T cell engineering, flow cytometry and sequencing analysis, in vivo experimental design and analysis.

Job Description

Job Responsibilities

• Molecular biology: cloning

• Viral (e.g. lentiviral) production, titration, characterization and validation

• In vitro T cell and HSC transduction: optimization of conditions, demonstration of on-target specificity

• In vivo experiments: injection of mice, in vivo imaging, bleeding/organ extraction and analysis using flow, microscopy and transcriptomic techniques (assisted by other lab members as needed)

• On-boarding, teaching, mentoring and supervision of junior lab members e.g. graduate students

• Perform data analysis and other aspects of quantitative and qualitative research as well as theoretical research

• Review, edit, format, and write manuscripts for publication and of grant proposals

• Assist with and often direct the design and implementation of original surveys

• Perform data collection and management

• Administer literature reviews

• Other research and administrative duties

• Oversee laboratory operations.

• Assist PI, graduate students, and postdoctoral fellows with experimental procedures and analysis.

• ,Grant development

• Data analysis

• Conduct biochemical and molecular biology assays, including chemical extractions, PCR, RT-PCR, sub-cloning, and Western blotting, animal ,Protocol Development.

• ,Other duties and responsibilities as assigned

Qualifications

• Doctor of Medicine, Doctor of Philosophy, and 5 to 7 years of postdoctoral experience is required.

This position is contingent upon grant funding.

Job Location - City, State<