Principal Research Scientist - Modeling and Simulation

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

The Local Delivery Translational Sciences (LDTS) organization at AbbVie, leads the strategy, generation, analyses, interpretations, and reporting of non-clinical data and communications/agreements with global regulatory agencies in the areas of Translational Pharmacology, Non-clinical Pharmacokinetics, Exposure-Response, Immunogenicity, and Biopharmaceutics.  The organization supports all phases of non-clinical development, supporting all new molecular entities across multiple therapeutic areas.

The organization is responsible for defining the relationship between drug exposure (e.g., concentrations in blood/ local tissue) and efficacy and safety measures in non-clinical models to select the optimal dose, dosing intervals, and biomarkers for FIH studies.

The organization provides critical support for conducting technical due diligence of new business opportunities (both in-licensing and out-licensing) by assessing probability of success for achieving the Target Product Profile (TPP). It also contributes to responses to defend our intellectual properties and extension of patent protection, provides critical support for life-cycle management of marketed products, responds to questions from post-marketing safety, legal, pharmaceutical manufacturing and regulatory for marketed products world-wide, and publication of scientific information in patents and manuscripts.

The LDTS group at AbbVie, is seeking a Principal Research Scientist – Modeling and Simulation.  As a member of multidisciplinary teams, this individual will contribute both Pharmacokinetic and Modeling and Simulation (M&S) expertise to lead efforts to build in silico drug models that describe the relationship(